Afloqualone
Based on 1 Customer Validation
Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 56287-74-2
- Formula: C16H14FN3O
- Molecular Weight:283.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Afloqualone (oral administration; 10-35 mg/kg; single dose) can relax γ-rigidity and α-rigidity in rats in a dose-dependent manner[1].
Afloqualone (oral administration; 5-10 mg/kg; single dose) inhibits vestibular nystagmus in a dose-dependent manner in spinalized cats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 56287-74-2
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Appearance Solid
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Molecular Weight 283.30
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Formula C16H14FN3O
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Color White to off-white
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SMILES
O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
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Synonyms
HQ-495
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 116.67 mg/mL (411.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. [Content Brief]
[2]. Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50(4):515-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5298 mL | 17.6491 mL | 35.2983 mL | 88.2457 mL |
| 5 mM | 0.7060 mL | 3.5298 mL | 7.0597 mL | 17.6491 mL | |
| 10 mM | 0.3530 mL | 1.7649 mL | 3.5298 mL | 8.8246 mL | |
| 15 mM | 0.2353 mL | 1.1766 mL | 2.3532 mL | 5.8830 mL | |
| 20 mM | 0.1765 mL | 0.8825 mL | 1.7649 mL | 4.4123 mL | |
| 25 mM | 0.1412 mL | 0.7060 mL | 1.4119 mL | 3.5298 mL | |
| 30 mM | 0.1177 mL | 0.5883 mL | 1.1766 mL | 2.9415 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8825 mL | 2.2061 mL | |
| 50 mM | 0.0706 mL | 0.3530 mL | 0.7060 mL | 1.7649 mL | |
| 60 mM | 0.0588 mL | 0.2942 mL | 0.5883 mL | 1.4708 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1031 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3530 mL | 0.8825 mL |
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