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Cat. No.: HY-117852

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CGP-59326

(Synonyms: TRX-13)

CGP-59326 (TRX-13) is a highly potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC₅₀=0.027 μM). CGP-59326 blocks the EGFR signaling pathwa, demonstrating highly selective inhibition of EGFR-dependent tumor cells. CGP-59326 is promising for research of cancers.

For research use only. We do not sell to patients.

CAS No.: 173458-56-5
Formula: C₁₄H₁₃ClN₄
Molecular Weight:272.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CGP-59326 Chemical Structure

CAS No.: 173458-56-5

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	1.5 mg/kg Compound: 13	In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R In vivo efficacy following oral administration in nude mouse tumor model, xenograft A431 cells expressing EGF-R	[PMID: 8691423]
A-431	IC₅₀	0.3 μM Compound: 13	Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R	[PMID: 8691423]
Balb/MK	IC₅₀	1.4 μM Compound: 13	Inhibition of proliferation of EGF-dependent BALB/MK cells Inhibition of proliferation of EGF-dependent BALB/MK cells	[PMID: 8691423]
NIH3T3	IC₅₀	>10 μM Compound: 13	Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells Inhibition of PDGF-stimulated tyrosine phosphorylation in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PDGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	>100 μM Compound: 13	Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells Inhibition of PMA/PKC-mediated c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]
NIH3T3	IC₅₀	2 μM Compound: 13	Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells Inhibition of EGF-induced c-fos mRNA expression in BALB/c 3T3 cells	[PMID: 8691423]

Chemical Information

CAS No. 173458-56-5
Molecular Weight 272.73
Formula C₁₄H₁₃ClN₄
SMILES

ClC1=CC=CC(NC2=NC=NC3=C2C(C)=C(C)N3)=C1
Synonyms

TRX-13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Traxler P, et al. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol Ther. 1999 May-Jun;82(2-3):195-206. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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