CL-283796
CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research.
For research use only. We do not sell to patients.
- CAS No.: 107376-72-7
- Formula: C28H41ClN2O
- Molecular Weight:457.09
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ACAT |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adult African green monkeys fed an atherogenic diet for approximately 6 weeks[1]
-
Dosage:10 and 30 mg/kg
-
Administration:p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks
-
Result:Resulted in a 24.1% reduction in total plasma cholesterol after 30 days (10 mg/kg dose).
Resulted in significant reductions in LDL cholesterol but non-significant effects on VLDL cholesterol values.
Showed no significant effects on plasma triglyceride values, HDL cholesterol, and apolipoproteins A-I, B and E levels.
Decreased the total plasma cholesterol (TPC)/HDL cholesterol ratios by 40% after 10 weeks.
Showed no significant effect on cholesterol absorption.
Did not affect body weights.
Chemical Information
-
CAS No. 107376-72-7
-
Molecular Weight 457.09
-
Formula C28H41ClN2O
-
SMILES
O=C(NC1=C(C)C=C(Cl)C=C1C)N(CCCCCCC)CC2=CC=C(CCC(C)C)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CL-283796 Related Classifications
HY-19251 Related Classifications
Powered by Bioz