LIMS1 - LIM zinc finger domain containing 1 Gene

Also Known as PINCH; PINCH1; PINCH-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3987

About LIMS1

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,533,671-108,687,246 (from NCBI)

This gene has 23 transcripts (splice variants), 30 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 18.5), adrenal (RPKM 16.0) and 25 other tissues.

Summary

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in Integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

LIMS1 Products (16)

mRNA Protein Name
NM_001193482.2 NP_001180411.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform c
NM_001193483.3 NP_001180412.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform d
NM_001193484.2 NP_001180413.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform e
NM_001193485.3 NP_001180414.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform a
NM_001193488.2 NP_001180417.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371494.1 NP_001358423.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform f
NM_001371495.1 NP_001358424.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform g
NM_001371496.1 NP_001358425.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform h
NM_001371497.1 NP_001358426.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform i
NM_001371498.1 NP_001358427.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371499.1 NP_001358428.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform j
NM_001371500.1 NP_001358429.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform k
NM_001394896.1 NP_001381825.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform l
NM_001394897.1 NP_001381826.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform m
NM_001394898.1 NP_001381827.1 LIM and senescent cell antigen-like-containing domain protein 1 isoform n
NM_004987.6 NP_004978.2 LIM and senescent cell antigen-like-containing domain protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10574708 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20926685 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
19074270 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
21390327 GOA
NOT involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in establishment of protein localization IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21390327 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21343177 GOA
involved in positive regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
20926685 GOA
NOT involved in regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20926685 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21343177 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IMP
IMP: Inferred from mutant phenotype
20926685 GOA
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
19117955 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
20926685 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21390327 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMS1 Protein Structure

LIM

LIM: LIM domain (10 - 66)

LIM

LIM: LIM domain (71 - 125)

LIM

LIM: LIM domain (135 - 186)

LIM

LIM: LIM domain (193 - 247)

LIM

LIM: LIM domain (252 - 306)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

LIM and senescent cell antigen-like-containing domain protein 1

  • LIM and senescent cell antigen-like domains 1

LIMS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIMS1 P48059 RSU1 Homo sapiens Q15404
Y2H Array
25416956
Intra
LIMS1 P48059 RSU1 Homo sapiens Q15404
Anti Tag CoIP
33961781
Intra
LIMS1 P48059 RSU1 Homo sapiens Q15404
Y2H Array
29892012
Intra
LIMS1 P48059 RSU1 Homo sapiens Q15404
Y2H Fragment Pooling
23414517
Cross
LIMS1 P48059 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross
LIMS1 P48059 Ilk Mus musculus O55222
ELISA
10574708
Cross
LIMS1 P48059 Ilk Mus musculus O55222
Anti Tag CoIP
11331308
Intra
LIMS1 P48059 NCK2 Homo sapiens O43639
NMR
15721255
Intra
LIMS1 P48059 NCK2 Homo sapiens O43639
ELISA
10574708
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
Anti Tag CoIP
33961781
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
Anti Tag CoIP
28514442
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
MAPPIT
25416956
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
Y2H Fragment Pooling
23414517
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
BiFC
23877428
Intra
LIMS1 P48059 ILK Homo sapiens Q13418
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

LIMS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84346 Pinch-1 Antibody (YA4043) WB, ICC/IF, FC, ELISA Human
HY-P84346A Pinch-1 Antibody (YA4043)(PBS only) WB, ICC/IF, FC, ELISA Human
HY-P85327 Pinch-1 Antibody (YA5019) WB, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Chromosome 3q13.31 Deletion Syndrome

  • 3q13 Microdeletion Syndrome

  • Monosomy 3q13

  • Chromosome 3, Monosomy 3q13

  • Del(3)(Q13)
Heinz Body Anemias

  • Heinz Body Anemia

  • Heinz Body Anemias, Alpha-

  • HEIBAN

  • Anemia, Heinz Body

  • Acquired Heinz Body Anemia
Focal Segmental Glomerulosclerosis

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Focal Glomerulosclerosis

  • Fsgs

  • Segmental Glomerulosclerosis

  • Glomerulosclerosis, Focal Segmental

  • Fgs

  • Focal Glomerular Sclerosis

  • Familial Idiopathic Nephrotic Syndrome

  • Focal Sclerosis With Hyalinosis

  • Glomerulosclerosis, Focal

  • Glomerulosclerosis Focal

  • Glomerulosclerosis, Segmental, Focal

  • Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07668 LIMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18827 Lims1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25318 Lims1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LIMS1 VGNC VGNC:81113
Macaca mulatta LIMS1 VGNC VGNC:74271
Rattus norvegicus LIMS1 RGD RGD:1560732
Bos taurus LIMS1 VGNC VGNC:50211
Mus musculus LIMS1 MGD MGI:1195263
Others LIMS1 NCBI