Semzuvolimab
Based on 1 Customer Validation
Semzuvolimab (UB421) is an anti-CD4 monoclonal antibody. Semzuvolimab binds to the CD4 receptor on cells, thereby preventing human immunodeficiency virus type 1 (HIV-1) from entering target cells.
For research use only. We do not sell to patients.
- Purity : 97%
- CAS No.: 2409099-32-5
- Molecular Weight:145.15 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
HIV-1 |
In Vitro
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1.5X1050 THP-1 cells with Semzuvolimab (HY-P9998, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Loaded Semzuvolimab on ProA biosensor, can bind HY-P70537 CD4 Protein, Human (HEK293, His) with an affinity constant of 6.956E-09 M as determined in BLI assay.
Chemical Information
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CAS No. 2409099-32-5
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Appearance Liquid
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Molecular Weight 145.15 kDa
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Color Colorless to light yellow
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SMILES
[Semzuvolimab]
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Synonyms
UB421
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)