Viridicatumtoxin
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
For research use only. We do not sell to patients.
- CAS No.: 39277-41-3
- Formula: C30H31NO10
- Molecular Weight:565.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)[2]
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Dosage:60-400 mg/kg
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Administration:i.p., p.o., s.c.
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Result:Orally with viridicatumtoxin had no signs of toxicity. As the dosage increasing (i.p. and p.o.), hepatocytes started to have pathological changes and deaths occurred in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. had no signs of toxicity and none died, but coagulation necrosis was present at the injection site.
Chemical Information
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CAS No. 39277-41-3
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Molecular Weight 565.57
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Formula C30H31NO10
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SMILES
O=C(C(C([C@@]12O)=O)=C(O)C[C@@]1(O)[C@H](O)C(C3=C[C@]4(C5=C3C(C(O)C=C5OC)=C6O)C(C)=CCCC4(C)C)=C6C2=O)N
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Structure Classification
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Initial Source
Penicillium viridicatum Westling
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Acute Systemic Toxicity Study
Acute systemic toxicity studies evaluate adverse effects occurring after a single exposure, or repeated exposure within a short acute window, and the main in vivo readouts are mortality, moribund condition, clinical signs, body-weight change, and gross pathological findings; acute oral toxicity methods were developed to replace classical LD50 testing with reduced-animal designs such as fixed-dose procedure, acute toxic class method, and up-and-down procedure. The fixed-dose procedure classifies acute toxicity by administering predefined dose levels and observing evident toxicity rather than using death as the primary endpoint, whereas the acute toxic class method uses sequential groups of three animals per step and the up-and-down procedure doses animals sequentially to estimate an LD50 with fewer animals than conventional LD50 testing.
Purity & Documentation
References
[1]. Hutchison RD, et al. Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling. Toxicol Appl Pharmacol. 1973;24(3):507-509. [Content Brief]
[2]. Bendele AM, Carlton WW, Nelson GE, Peterson RE, Grove MD. Viridicatumtoxin mycotoxicosis in mice and rats. Toxicol Lett. 1984;22(3):287-291. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Viridicatumtoxin Related Classifications
HY-129208 Related Classifications
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