1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. VU6000918

VU6000918 

Cat. No.: HY-139044
Handling Instructions

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4.

For research use only. We do not sell to patients.

VU6000918 Chemical Structure

VU6000918 Chemical Structure

CAS No. : 2101737-32-8

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Description

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC50 of 19 nM for hM4[1].

IC50 & Target

EC50: 19 nM (hM4)[1].

In Vitro

VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.42

Formula

C₁₈H₁₇F₂N₅OS

CAS No.
SMILES

O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NC3CN(C4=CC=CC(F)=C4F)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

VU6000918VU 6000918VU-6000918mAChRMuscarinic acetylcholine receptorM4PAMhyperlocomotionP-gpInhibitorinhibitorinhibit

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VU6000918
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