2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. VUF-6884

VUF-6884 (Compound 7j) is a histamine receptor (Histamine Receptor) ligand with activity toward human H4R and H1R. Its pEC50 and pKi values against human H4R are 7.70 and 7.55, respectively, while those against human H1R are 8.17 and 8.11, respectively. VUF-6884 competitively binds to the orthosteric binding site of human H4R to displace histamine, and exhibits inverse agonist activity at human H1R.

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VUF-6884

VUF-6884 Chemical Structure

CAS No. : 3455-10-5

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VUF-6884 Related Antibodies

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Description

VUF-6884 (Compound 7j) is a histamine receptor (Histamine Receptor) ligand with activity toward human H4R and H1R. Its pEC50 and pKi values against human H4R are 7.70 and 7.55, respectively, while those against human H1R are 8.17 and 8.11, respectively. VUF-6884 competitively binds to the orthosteric binding site of human H4R to displace histamine, and exhibits inverse agonist activity at human H1R[1].

Molecular Weight

327.81

Formula

C18H18ClN3O
CAS No.
SMILES

ClC1=CC=C2N=C(C=3C=CC=CC3OC2=C1)N4CCN(C)CC4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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VUF-6884 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VUF-68843455-10-5VUF6884VUF 6884Histamine Receptorhuman H1Rhuman H4Rhistamine receptor ligandhuman H2Rorthosteric binding siteinverse agonistic propertiesCRE-β-galactosidase reporter genehistaminehuman H3RSK-N-MC cellsInhibitorinhibitorinhibit

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