2. Apoptosis
  3. c-Myc Apoptosis
  4. Y502-3888

Y502-3888 is a c-Myc inhibitor. Y502-3888 binds to the c-Myc G4 structure, inhibits c-Myc transcription, and downregulates c-Myc expression at both mRNA and protein levels. Y502-3888 inhibits the viability of myeloma cells and induces cell apoptosis. Y502-3888 can be used for the research of multiple myeloma.

For research use only. We do not sell to patients.

Y502-3888

Y502-3888 Chemical Structure

CAS No. : 828292-11-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Y502-3888 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Y502-3888 is a c-Myc inhibitor. Y502-3888 binds to the c-Myc G4 structure, inhibits c-Myc transcription, and downregulates c-Myc expression at both mRNA and protein levels. Y502-3888 inhibits the viability of myeloma cells and induces cell apoptosis. Y502-3888 can be used for the research of multiple myeloma[1].

In Vitro

Y502-3888 (1-30 μM; 48 h) potently and selectively inhibits the viability of human multiple myeloma RPMI 8226 and U266 cells, with IC50 values of 12.67 μM and 7.03 μM, respectively, and minimal toxicity to non-malignant HEK293T cells[1].
Y502-3888 (5-20 μM; 48 h) dose-dependently induces apoptosis in human multiple myeloma U266 cells, with increasing proportions of early and late apoptotic cells at concentrations of 5, 10, and 20 μM[1].
Y502-3888 (5-20 μM; 48 h) dose-dependently downregulates c-Myc protein expression in human multiple myeloma U266 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Y502-3888 Related Antibodies

Apoptosis Analysis[1]

Cell Line: Human multiple myeloma U266 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Induced dose-dependent increases in apoptotic cell populations.Resulted in 8.68% early apoptotic and 15.4% late apoptotic cells at 5 μM.
Resulted in 16.2% early apoptotic and 26.2% late apoptotic cells at 10 μM.
Resulted in 24.9% early apoptotic and 57.0% late apoptotic cells at 20 μM.

Western Blot Analysis[1]

Cell Line: Human multiple myeloma U266 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Reduced c-Myc protein levels in a dose-dependent manner.
Caused statistically significant reductions in c-Myc protein levels at 10 μM and 20 μM relative to control cells.
Markedly decreased c-Myc protein levels at 20 μM.

Real Time qPCR[1]

Cell Line: Human multiple myeloma U266 cells, CA46 Burkitt's lymphoma cells
Concentration: 5, 10 and 20 μM
Incubation Time: 48 h
Result: Reduced c-Myc mRNA levels in U266 cells in a dose-dependent manner, with expression reduced to ~50% of control at 20 μM.
Dose-dependently suppressed Exon 1 c-Myc mRNA levels in CA46 cells, with minimal effect on Exon 2 levels.
Molecular Weight

410.45

Formula

C19H18N6O3S
CAS No.
SMILES

CCN(C(C1=C(C2=C(S1)N=CN3N=C(N=C23)C4=CC=CC=C4[N+]([O-])=O)C)=O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Y502-3888 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y502-3888828292-11-1c-MycApoptosisMycc-Myc transcriptionmultiple myelomac-Myc G-quadruplex DNA structurec-Myc proteinHEK293T cellsU266 cellsc-Myc mRNAtelomeric G-quadruplexCA46 Burkitt's lymphoma cellsRPMI 8226 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Y502-3888
Cat. No.:
HY-181234
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.