2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Ziv-aflibercept

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases.

For research use only. We do not sell to patients.

Ziv-aflibercept Chemical Structure

Ziv-aflibercept Chemical Structure

CAS No. : 1609655-49-3

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Based on 1 publication(s) in Google Scholar

Ziv-aflibercept Related Antibodies

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Description

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2].

In Vitro

Ziv-aflibercept (0.25, 0.5, 1.0 and 5 mg/mL; 24 h) reduces mitochondrial membrane potential in ARPE-19 cells with dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziv-aflibercept Related Antibodies

Cell Viability Assay[1]

Cell Line: ARPE-19 cells.
Concentration: 0.25, 0.5, 1.0 and 5 mg/mL.
Incubation Time: 24 h.
Result: Insignificantly affected cell viability (below 1 mg/mL).
In Vivo

Ziv-aflibercept (25 mg/mL; intravitreal injection; single dose) insignificantly causes cataract, retinal detachment and other related complications in the right eye of the rabbit[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ziv-aflibercept]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Ziv-aflibercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziv-aflibercept1609655-49-3VEGFRVascular endothelial growth factor receptorARPE-19 cellsRabbitInhibitorinhibitorinhibit

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