ZNL-0056
ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2767987-38-0
- Formula: C25H27N5O3S
- Molecular Weight:477.58
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
In Vivo
Pharmacokinetic Analysis in Male C57BL/6 Mice Model[1]
| Route | Dose (mg/kg) | T1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUClast (ng·min/mL) | AUCINF_obs (ng·min/mL) | AUC%Extrap (ng·min/mL) | Clobs (mL·min/kg) | MRTINF_obs (h) | F (%) |
| i.v. | 1 | 0.33 | 0.08 | 965 | 21820 | 22013 | 0.86 | 53.6 | 0.30 | / |
| i.p. | 3 | 0.49 | 0.19 | 611 | 27398 | 27482 | 0.39 | 142.9 | / | 41.9 |
| p.o. | 10 | 3.8 | 0.14 | 658 | 53219 | 63341 | 15.7 | 158.8 | / | 24.4 |