2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. ZNL-0056

ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer.

For research use only. We do not sell to patients.

ZNL-0056 Chemical Structure

ZNL-0056 Chemical Structure

CAS No. : 2767987-38-0

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ZNL-0056 Related Antibodies

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Description

ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer[1].

In Vivo


Pharmacokinetic Analysis in Male C57BL/6 Mice Model[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUClast (ng·min/mL) AUCINF_obs (ng·min/mL) AUC%Extrap (ng·min/mL) Clobs (mL·min/kg) MRTINF_obs (h) F (%)
i.v. 1 0.33 0.08 965 21820 22013 0.86 53.6 0.30 /
i.p. 3 0.49 0.19 611 27398 27482 0.39 142.9 / 41.9
p.o. 10 3.8 0.14 658 53219 63341 15.7 158.8 / 24.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

477.58

Formula

C25H27N5O3S
CAS No.
SMILES

O=C(C1=CSC(NC(C=C)=O)=C1)NC2=NC3=CC=CC(C)=C3N2[C@H]4CN(CCCC4)C(C=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZNL-0056 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZNL-00562767987-38-0ZNL0056ZNL 0056EGFREpidermal growth factor receptorErbB-1HER1Cys797Cys775cancerEGFR Ba/F3H3255Inhibitorinhibitorinhibit

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