2. Apoptosis
  3. Apoptosis
  4. β-Apopicropodophyllin

β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer.

For research use only. We do not sell to patients.

β-Apopicropodophyllin Chemical Structure

β-Apopicropodophyllin Chemical Structure

CAS No. : 477-52-1

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β-Apopicropodophyllin Related Antibodies

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Description

β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer[1].

In Vitro

β-Apopicropodophyllin (0-100 nM; 48 and 72 h) has anti-cancer activity against A549, NCI-H1299 and NCI-460 cell lines with IC50 values of 16.9, 13.1 and 17.1 nM, respectively[1].
β-Apopicropodophyllin (0-20 nM; 24 and 48 h; A549, NCI-H1299 and NCI-460 cell lines) disrupts polymerization of intracellular microtubules[1].
β-Apopicropodophyllin (0-20 nM; 0-24 h; A549, NCI-H1299 and NCI-460 cell lines) induces DNA damage via activation of ATM, arrests cell cycle in G2/M phase and induces endoplasmic reticulum (ER) stress[1].
β-Apopicropodophyllin (15 and 20 nM; 48 h; A549, NCI-H1299 and NCI-460 cell lines) induces apoptotic cell death in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Apopicropodophyllin Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-100 nM
Incubation Time: 48 and 72 hors
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 15 and 20 nM
Incubation Time: 48 h
Result: Increased the percentage of apoptotic death in A549, NCI-H1299 and NCI-H460 cell groups in a time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 8 and 16 h
Result: Arrested cell cycle in G2/M phase.

Western Blot Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 24 and 48 hors
Result: Decreased the level of insoluble protein containing polymeric microtubules in a time-dependent manner in non-small cell lung cancer cell lines.

Western Blot Analysis[1]

Cell Line: A549, NCI-H1299 and NCI-460 cells
Concentration: 0-20 nM
Incubation Time: 24 h
Result: Increased phosphorylated ATM and γ-H2AX levels in a dose-dependent manner.
In Vivo

β-Apopicropodophyllin (1 and 5 mg/kg; intra-tumorous injection; nude mice with xenografts) retards tumor growth in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nude mice with xenografts[1]
Dosage: 1 and 5 mg/kg
Administration: intra-tumorous injection
Result: Inhibited tumor growth of NSCLC xenografts in nude mice.
Molecular Weight

396.39

Formula

C22H20O7
CAS No.
SMILES

O=C1C2=C(CO1)CC3=CC4=C(OCO4)C=C3[C@H]2C5=CC(OC)=C(C(OC)=C5)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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β-Apopicropodophyllin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Apopicropodophyllin477-52-1Apoptosisnature productHyptis wticillatamicrotubule disruptionDNA damagecancerInhibitorinhibitorinhibit

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