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Cat. No.: HY-N11600

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β-Apopicropodophyllin

β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No.: 477-52-1
Formula: C₂₂H₂₀O₇
Molecular Weight:396.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

β-Apopicropodophyllin Chemical Structure

CAS No.: 477-52-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

β-Apopicropodophyllin (0-100 nM; 48 and 72 h) has anti-cancer activity against A549, NCI-H1299 and NCI-460 cell lines with IC₅₀ values of 16.9, 13.1 and 17.1 nM, respectively^[1].
β-Apopicropodophyllin (0-20 nM; 24 and 48 h; A549, NCI-H1299 and NCI-460 cell lines) disrupts polymerization of intracellular microtubules^[1].
β-Apopicropodophyllin (0-20 nM; 0-24 h; A549, NCI-H1299 and NCI-460 cell lines) induces DNA damage via activation of ATM, arrests cell cycle in G2/M phase and induces endoplasmic reticulum (ER) stress^[1].
β-Apopicropodophyllin (15 and 20 nM; 48 h; A549, NCI-H1299 and NCI-460 cell lines) induces apoptotic cell death in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549, NCI-H1299 and NCI-460 cells
Concentration:

0-100 nM
Incubation Time:

48 and 72 hors
Result:

Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

A549, NCI-H1299 and NCI-460 cells
Concentration:

15 and 20 nM
Incubation Time:

48 h
Result:

Increased the percentage of apoptotic death in A549, NCI-H1299 and NCI-H460 cell groups in a time-dependent manner.

Cell Cycle Analysis^[1]

Cell Line:

A549, NCI-H1299 and NCI-460 cells
Concentration:

0-20 nM
Incubation Time:

8 and 16 h
Result:

Arrested cell cycle in G2/M phase.

Western Blot Analysis^[1]

Cell Line:

A549, NCI-H1299 and NCI-460 cells
Concentration:

0-20 nM
Incubation Time:

24 and 48 hors
Result:

Decreased the level of insoluble protein containing polymeric microtubules in a time-dependent manner in non-small cell lung cancer cell lines.

Western Blot Analysis^[1]

Cell Line:

A549, NCI-H1299 and NCI-460 cells
Concentration:

0-20 nM
Incubation Time:

24 h
Result:

Increased phosphorylated ATM and γ-H2AX levels in a dose-dependent manner.

In Vivo

β-Apopicropodophyllin (1 and 5 mg/kg; intra-tumorous injection; nude mice with xenografts) retards tumor growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nude mice with xenografts^[1]
Dosage:

1 and 5 mg/kg
Administration:

intra-tumorous injection
Result:

Inhibited tumor growth of NSCLC xenografts in nude mice.

Chemical Information

CAS No. 477-52-1
Molecular Weight 396.39
Formula C₂₂H₂₀O₇
SMILES

O=C1C2=C(CO1)CC3=CC4=C(OCO4)C=C3[C@H]2C5=CC(OC)=C(C(OC)=C5)OC
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JY, et, al. A novel anti-cancer role of β-apopicropodophyllin against non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2018 Oct 15;357:39-49. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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