Cat. No.: HY-W015084

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β-Ionone

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Based on 1 publication(s) in Google Scholar

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 14901-07-6
Formula: C₁₃H₂₀O
Molecular Weight:192.30

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

β-Ionone Chemical Structure

CAS No.: 14901-07-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	210 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by flow cytometry Antiproliferative activity against human DU145 cells after 72 hrs by flow cytometry	[PMID: 27474930]
LNCaP	IC₅₀	130 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 72 hrs by flow cytometry Antiproliferative activity against human LNCAP cells after 72 hrs by flow cytometry	[PMID: 27474930]
LNCaP	IC₅₀	151 μM Compound: Beta-ionone	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19725582]
MCF7	IC₅₀	104 μM Compound: 1	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 27474930]
MDA-MB-435	IC₅₀	42 μM Compound: 1	Growth inhibition of human MDA-MB-435 cells after 7 days relative to control Growth inhibition of human MDA-MB-435 cells after 7 days relative to control	[PMID: 27474930]
PC-3	IC₅₀	130 μM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by flow cytometry Antiproliferative activity against human PC3 cells after 72 hrs by flow cytometry	[PMID: 27474930]
SGC-7901	IC₅₀	174.93 μM Compound: 1	Antiproliferative activity against human SGC7901 cells Antiproliferative activity against human SGC7901 cells	[PMID: 27474930]
SGC-7901	IC₅₀	89 μM Compound: 1	Growth inhibition of human SGC7901 cells after 24 to 48 hrs by MTT assay Growth inhibition of human SGC7901 cells after 24 to 48 hrs by MTT assay	[PMID: 27474930]

In Vitro

β-Ionone is an analog of β-carotenoids which widely distributed in fruit and vegetables^[1].
β-ionone (25, 50, 100 and 200 μM; for 24 and 48 h) inhibits SGC-7901 cell line growth. The measured IC₅₀ value is 89 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 14901-07-6
Appearance Liquid (Density: 0.944±0.06 g/cm³)
Molecular Weight 192.30
Formula C₁₃H₂₀O
Color Colorless to light yellow
SMILES

CC(/C=C/C1=C(C)CCCC1(C)C)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Pharmacol Res

Microbiota-derived acetate suppresses sympathetic outflow via olfactory receptor 59 in the rostral ventrolateral medulla. [Abstract]

2025 May 7:107766. PMID: 40345351

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (520.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (520.02 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.2002 mL

26.0010 mL

52.0021 mL

5 mM

1.0400 mL

5.2002 mL

10.4004 mL

10 mM

0.5200 mL

2.6001 mL

5.2002 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mahsa Ansari, et al. β-Ionone and Its Analogs as Promising Anticancer Agents. Eur J Med Chem. 2016 Nov 10;123:141-154. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	5.2002 mL	26.0010 mL	52.0021 mL	130.0052 mL
	5 mM	1.0400 mL	5.2002 mL	10.4004 mL	26.0010 mL
	10 mM	0.5200 mL	2.6001 mL	5.2002 mL	13.0005 mL
	15 mM	0.3467 mL	1.7334 mL	3.4668 mL	8.6670 mL
	20 mM	0.2600 mL	1.3001 mL	2.6001 mL	6.5003 mL
	25 mM	0.2080 mL	1.0400 mL	2.0801 mL	5.2002 mL
	30 mM	0.1733 mL	0.8667 mL	1.7334 mL	4.3335 mL
	40 mM	0.1300 mL	0.6500 mL	1.3001 mL	3.2501 mL
	50 mM	0.1040 mL	0.5200 mL	1.0400 mL	2.6001 mL
	60 mM	0.0867 mL	0.4334 mL	0.8667 mL	2.1668 mL
	80 mM	0.0650 mL	0.3250 mL	0.6500 mL	1.6251 mL
	100 mM	0.0520 mL	0.2600 mL	0.5200 mL	1.3001 mL

Keywords

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β-Ionone

Apoptosis Compound Library

Natural Product Library

Anti-Cancer Compound Library

Medicine Food Homology Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Flavors and Fragrances Compound Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Environmental Pollutant Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) β-Ionone

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

β-Ionone Related Classifications

Cat. No.: HY-W015084