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Cat. No.: HY-W403933

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12-Ketochenodeoxycholic acid

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12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 2458-08-4
Formula: C₂₄H₃₈O₅
Molecular Weight:406.56

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

12-Ketochenodeoxycholic acid Chemical Structure

CAS No.: 2458-08-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases^[1]^[2].

All Endogenous Metabolite Isoforms :

In Vitro

12-Ketochenodeoxycholic acid arises from dehydrocholic acid via microbial transformation by Brevibacterium fuscum or Lactobacillus xylosus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2458-08-4
Appearance Solid
Molecular Weight 406.56
Formula C₂₄H₃₈O₅
Color White to off-white
SMILES

C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Lactobacillus xylosus
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (245.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4597 mL

12.2983 mL

24.5966 mL

5 mM

0.4919 mL

2.4597 mL

4.9193 mL

10 mM

0.2460 mL

1.2298 mL

2.4597 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sawada H, et al. Microbial production of chenodeoxycholic acid precursor, 12-ketochenodeoxycholic acid, from dehydrocholic acid[J]. European journal of applied microbiology and biotechnology, 1980, 10(1): 107-112.

[2]. Kikuchi H. The metabolic sequence for the occurrence of an anomalous bile acid, 12-ketochenodeoxycholic acid, found in the bile of hepatobiliary diseased patients[J]. The Journal of Biochemistry, 1972, 72(1): 165-172.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4597 mL	12.2983 mL	24.5966 mL	61.4915 mL
	5 mM	0.4919 mL	2.4597 mL	4.9193 mL	12.2983 mL
	10 mM	0.2460 mL	1.2298 mL	2.4597 mL	6.1492 mL
	15 mM	0.1640 mL	0.8199 mL	1.6398 mL	4.0994 mL
	20 mM	0.1230 mL	0.6149 mL	1.2298 mL	3.0746 mL
	25 mM	0.0984 mL	0.4919 mL	0.9839 mL	2.4597 mL
	30 mM	0.0820 mL	0.4099 mL	0.8199 mL	2.0497 mL
	40 mM	0.0615 mL	0.3075 mL	0.6149 mL	1.5373 mL
	50 mM	0.0492 mL	0.2460 mL	0.4919 mL	1.2298 mL
	60 mM	0.0410 mL	0.2050 mL	0.4099 mL	1.0249 mL
	80 mM	0.0307 mL	0.1537 mL	0.3075 mL	0.7686 mL
	100 mM	0.0246 mL	0.1230 mL	0.2460 mL	0.6149 mL

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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12-Ketochenodeoxycholic acid

Metabolism/Protease Compound Library

Natural Product Library

Lipid Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Human Metabolite Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Bile Acids Library

Mass Spectrometry Human Metabolite Library

Mass Spectrometry Natural Product Library

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

12-Ketochenodeoxycholic acid

Metabolism/Protease Compound Library

Natural Product Library

Lipid Compound Library

Gut Microbial Metabolite Library

Microbial Metabolite Library

Human Metabolite Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Bile Acids Library

Mass Spectrometry Human Metabolite Library

Mass Spectrometry Natural Product Library

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

12-Ketochenodeoxycholic acid Related Classifications

HY-W403933 Related Classifications