12-Oxocalanolide A
12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC50 and EC50 of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide.
For research use only. We do not sell to patients.
- CAS No.: 161753-49-7
- Formula: C22H24O5
- Molecular Weight:368.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AA5 | EC50 |
2.8 μM
Compound: (+/-)-2
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Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell
Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell
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[PMID: 9873509] |
| B-cell | EC50 |
>10 μM
Compound: (+)-2
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Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell
Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell
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[PMID: 9873509] |
| CCRF-CEM | EC50 |
1.09 μM
Compound: (+)-2
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Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells
Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells
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[PMID: 9873509] |
| CCRF-CEM | EC50 |
>10 μM
Compound: (+)-2
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Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion
Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion
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[PMID: 9873509] |
| CEM-SS | EC50 |
0.15 μM
Compound: 10
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Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
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[PMID: 8893846] |
| CEM-SS | IC50 |
9.3 μM
Compound: 10
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Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined
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[PMID: 8893846] |
| CEM-SS | EC50 |
1.2 μM
Compound: (+/-)5
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Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined
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[PMID: 9083491] |
| CEM-SS | IC50 |
19 μM
Compound: (+/-)5
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Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls
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[PMID: 9083491] |
| CEM-SS | EC50 |
0.52 μM
Compound: (+/-)-2
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Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50
Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50
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[PMID: 9873509] |
Chemical Information
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CAS No. 161753-49-7
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Molecular Weight 368.42
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Formula C22H24O5
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SMILES
O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C4C(C([C@H](C)[C@@H](C)O4)=O)=C2O1
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Synonyms
(±)-12-Oxocalanolide A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
12-Oxocalanolide A Related Classifications
HY-N1034 Related Classifications
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