3-Fluoro-evodiamine glucose
Based on 1 Customer Validation
3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity.
For research use only. We do not sell to patients.
- Purity: 99.95%
- Formula: C25H26FN3O7
- Molecular Weight:499.49
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Topoisomerase I |
Topoisomerase II |
GLUT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.064 μM
Compound: 8
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Antiproliferative activity against human A549 cells measured after 72 hrs by CCK-8 cells
Antiproliferative activity against human A549 cells measured after 72 hrs by CCK-8 cells
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[PMID: 38646851] |
| HCT-116 | IC50 |
0.064 μM
Compound: 8
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Antiproliferative activity against human HCT116 cells measured after 72 hrs by CCK-8 cells
Antiproliferative activity against human HCT116 cells measured after 72 hrs by CCK-8 cells
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[PMID: 38646851] |
| HCT-116 | IC50 |
0.21 μM
Compound: 8
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Antiproliferative activity against human HCT116 cells in presence of 5 uM phloretin measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells in presence of 5 uM phloretin measured after 72 hrs by CCK-8 assay
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[PMID: 38646851] |
| HCT-116 | IC50 |
0.43 μM
Compound: 8
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Antiproliferative activity against human HCT116 cells in presence of 10 uM phloretin measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells in presence of 10 uM phloretin measured after 72 hrs by CCK-8 assay
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[PMID: 38646851] |
| HUVEC | IC50 |
0.221 μM
Compound: 8
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Cytotoxicity against HUVEC after 72 hrs by CCK-8 assay
Cytotoxicity against HUVEC after 72 hrs by CCK-8 assay
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[PMID: 38646851] |
| U-87MG ATCC | IC50 |
0.064 μM
Compound: 8
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Antiproliferative activity against human U-87 MG cells measured after 72 hrs by CCK-8 cells
Antiproliferative activity against human U-87 MG cells measured after 72 hrs by CCK-8 cells
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[PMID: 38646851] |
3-Fluoro-evodiamine glucose (0-0.5 μM, 12 h) exhibits antiproliferative and cytotoxic property in cancer cells U87MG, A549 and HCT116 with IC50 range of 0.064–0.113 μM, through induction of reactive oxygen species (ROS) accumulation and DNA damage[1].
3-Fluoro-evodiamine glucose (0-0.05 μM, 24 h) inhibits the migration and invasion of cell HCT116 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3-Fluoro-evodiamine glucose (10-20 mg/kg, ip, twice daily for 21 days) exhibits antitumor efficacy with a tumor growth inhibition TGI of 72%-82% in HCT116 xenograft nude mice, without significant toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCT116 xenograft BALB/c nude mice[1]
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Dosage:10-20 mg/kg
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Administration:ip, two injections every days for 21 days
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Result:Inhibited tumor growth with TGI of 72-82%, without body weight loss.
Chemical Information
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Appearance Solid
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Molecular Weight 499.49
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Formula C25H26FN3O7
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Color Off-white to light yellow
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SMILES
O[C@H]1[C@@H]([C@H]([C@@H](O[C@@H]1CO)OC2=CC3=C(NC4=C3CCN5[C@]4([H])N(C6=C(C5=O)C=C(F)C=C6)C)C=C2)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (100.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0020 mL | 10.0102 mL | 20.0204 mL | 50.0511 mL |
| 5 mM | 0.4004 mL | 2.0020 mL | 4.0041 mL | 10.0102 mL | |
| 10 mM | 0.2002 mL | 1.0010 mL | 2.0020 mL | 5.0051 mL | |
| 15 mM | 0.1335 mL | 0.6673 mL | 1.3347 mL | 3.3367 mL | |
| 20 mM | 0.1001 mL | 0.5005 mL | 1.0010 mL | 2.5026 mL | |
| 25 mM | 0.0801 mL | 0.4004 mL | 0.8008 mL | 2.0020 mL | |
| 30 mM | 0.0667 mL | 0.3337 mL | 0.6673 mL | 1.6684 mL | |
| 40 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.2513 mL | |
| 50 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0010 mL | |
| 60 mM | 0.0334 mL | 0.1668 mL | 0.3337 mL | 0.8342 mL | |
| 80 mM | 0.0250 mL | 0.1251 mL | 0.2503 mL | 0.6256 mL | |
| 100 mM | 0.0200 mL | 0.1001 mL | 0.2002 mL | 0.5005 mL |
3-Fluoro-evodiamine glucose Related Classifications
HY-161501 Related Classifications
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