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    Apoptosis
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    Apoptosis
  3. 4-Epianhydrotetracycline hydrochloride

4-Epianhydrotetracycline hydrochloride 

Cat. No.: HY-136439
Handling Instructions

4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively.

For research use only. We do not sell to patients.

4-Epianhydrotetracycline hydrochloride Chemical Structure

4-Epianhydrotetracycline hydrochloride Chemical Structure

CAS No. : 4465-65-0

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Description

4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively[1].

IC50 & Target

Tetracycline

 

In Vitro

4-Epianhydrotetracycline hydrochloride (0-20 mg/L; 96 h) significantly enhances ROS levels, and malondialdehyde (MDA) concentration and protein carbonyl (PC) content with increasing concentration of 5-20.0 mg/L[1].
4-Epianhydrotetracycline hydrochloride (0-20 mg/L; 96 h) dose-dependently affects SOD activities with increasing first and then decreasing, and at a dose of 2.50 mg/L SOD activity reached the highest value[1].
4-Epianhydrotetracycline hydrochloride (0-20 mg/L; 96 h) induces cell apoptosis[1].
4-Epianhydrotetracycline hydrochloride (0-100 mg/L) shows lethal effects of zebrafish embryos with an LC50 value of 29.13 mg/L at 96 h[2].
4-Epianhydrotetracycline hydrochloride increases zebrafish embryos malformation with an EC50 value of 8.57 mg/L at 96 h[2].
4-Epianhydrotetracycline hydrochloride inhibits the heart rate (10-20 mg/L) and shows delayed hatching effects (5-20.0 mg/L) [2].
4-Epianhydrotetracycline hydrochloride (0-20 mg/L) shows inhibitory effects to Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Zebrafish embryos
Concentration: 0, 1.25, 2.5, 5, 10 and 20 mg/L
Incubation Time: 96 hours
Result: Dose-dependently induced cell apoptosis with 66.67% zebrafish embryos showed apoptosis phenomenon at a dose of 20.0 mg/L.
Molecular Weight

462.88

Formula

C22H23ClN2O7

CAS No.
SMILES

O[[email protected]@](C(C1=C(C2=C3O)O)=O)(C(C(C(N)=O)=C4O)=O)[[email protected]](CC1=C(C2=CC=C3)C)([H])[[email protected]]4N(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
4-Epianhydrotetracycline hydrochloride
Cat. No.:
HY-136439
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