9-Hydroxy-α-lapachone
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC50 of 4.64 µM on LPS-induced NO production in RAW 264.7 cells.
For research use only. We do not sell to patients.
- CAS No.: 22333-58-0
- Formula: C15H14O4
- Molecular Weight:258.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HBL-100 | GI50 |
3.4 μM
Compound: 3a, 9-hydroxy-alpha-lapachone
|
Growth inhibition of human HBL100 cells by SRB assay
Growth inhibition of human HBL100 cells by SRB assay
|
[PMID: 22560628] |
| HeLa | GI50 |
1.8 μM
Compound: 3a, 9-hydroxy-alpha-lapachone
|
Growth inhibition of human HeLa cells by SRB assay
Growth inhibition of human HeLa cells by SRB assay
|
[PMID: 22560628] |
| SW1573 | GI50 |
19 μM
Compound: 3a, 9-hydroxy-alpha-lapachone
|
Growth inhibition of human SW1573 cells by SRB assay
Growth inhibition of human SW1573 cells by SRB assay
|
[PMID: 22560628] |
| WiDr | GI50 |
14 μM
Compound: 3a, 9-hydroxy-alpha-lapachone
|
Growth inhibition of human WiDr cells by SRB assay
Growth inhibition of human WiDr cells by SRB assay
|
[PMID: 22560628] |
Chemical Information
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CAS No. 22333-58-0
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Molecular Weight 258.27
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Formula C15H14O4
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SMILES
O=C(C1=C2OC(C)(C)CC1)C3=C(C2=O)C(O)=CC=C3
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Synonyms
α-Dihydrocaryopterone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)