1. Cell Cycle/DNA Damage Epigenetics
  2. Aurora Kinase
  3. Aurora inhibitor 1

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively.

For research use only. We do not sell to patients.

Aurora inhibitor 1 Chemical Structure

Aurora inhibitor 1 Chemical Structure

CAS No. : 2227019-45-4

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Description

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].

IC50 & Target[1]

Aurora A

4 nM (IC50)

Aurora B

13 nM (IC50)

In Vitro

Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

459.57

Formula

C23H25N9S

CAS No.
SMILES

CC(N=C1NC2=CC(C(C3=CC=CC=N3)NC(C)(C)C)=NS2)=CN4C1=NC=C4C5=CNN=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Aurora inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Aurora inhibitor 1
Cat. No.:
HY-111506
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