1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

Aurora inhibitor 1 

Cat. No.: HY-111506
Handling Instructions

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively.

For research use only. We do not sell to patients.

Aurora inhibitor 1 Chemical Structure

Aurora inhibitor 1 Chemical Structure

CAS No. : 2227019-45-4

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View All Aurora Kinase Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].

IC50 & Target[1]

Aurora A

4 nM (IC50)

Aurora B

13 nM (IC50)

In Vitro

Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1].

In Vivo

Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1759 mL 10.8797 mL 21.7595 mL
5 mM 0.4352 mL 2.1759 mL 4.3519 mL
10 mM 0.2176 mL 1.0880 mL 2.1759 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

459.57

Formula

C₂₃H₂₅N₉S

CAS No.

2227019-45-4

SMILES

CC(N=C1NC2=CC(C(C3=CC=CC=N3)NC(C)(C)C)=NS2)=CN4C1=NC=C4C5=CNN=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Aurora inhibitor 1
Cat. No.:
HY-111506
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Aurora inhibitor 1

Cat. No.: HY-111506