1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. CCI-006

CCI-006 

Cat. No.: HY-114410 Purity: 98.79%
Handling Instructions

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells.

For research use only. We do not sell to patients.

CCI-006 Chemical Structure

CCI-006 Chemical Structure

CAS No. : 292053-42-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].

IC50 & Target

Mitochondria[1].

Molecular Weight

332.33

Formula

C₁₅H₁₂N₂O₅S

CAS No.

292053-42-0

SMILES

O=C(/C(C#N)=C/C1=CC=C(C2=CC=C(S(=O)(N)=O)C=C2)O1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (250.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0091 mL 15.0453 mL 30.0906 mL
5 mM 0.6018 mL 3.0091 mL 6.0181 mL
10 mM 0.3009 mL 1.5045 mL 3.0091 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 8.33 mg/mL (25.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CCI-006CCI006CCI 006Mitochondrial MetabolismInhibitorinhibitorinhibit

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Product name:
CCI-006
Cat. No.:
HY-114410
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