CHK1-IN-2
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 912367-45-4
- 分子式: C20H22N4OS
- 分子量:366.48
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
Chk1 6 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | GI50 |
306 nM
Compound: 44
|
Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
|
[PMID: 29301085] |
| NCI-H460 | GI50 |
2453 nM
Compound: 44
|
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
|
[PMID: 29301085] |
| SW-620 | GI50 |
725 nM
Compound: 44
|
Antiproliferative activity against human SW620 cells
Antiproliferative activity against human SW620 cells
|
[PMID: 29301085] |
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 912367-45-4
-
分子量 366.48
-
分子式 C20H22N4OS
-
SMILES
O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CHK1-IN-2 関連分類
HY-111369 関連分類
Powered by Bioz