1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)

CHK1-IN-2 

Cat. No.: HY-111369
Handling Instructions

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.

For research use only. We do not sell to patients.

CHK1-IN-2 Chemical Structure

CHK1-IN-2 Chemical Structure

CAS No. : 912367-45-4

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View All Checkpoint Kinase (Chk) Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.

IC50 & Target[1]

Chk1

6 nM (IC50)

In Vitro

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7287 mL 13.6433 mL 27.2866 mL
5 mM 0.5457 mL 2.7287 mL 5.4573 mL
10 mM 0.2729 mL 1.3643 mL 2.7287 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

366.48

Formula

C₂₀H₂₂N₄OS

CAS No.

912367-45-4

SMILES

O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[[email protected]@H]4[[email protected]@H](C)NCCC4)N=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CHK1-IN-2
Cat. No.:
HY-111369
Quantity:

CHK1-IN-2

Cat. No.: HY-111369