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Clascoterone (Synonyms: Cortexolone 17 alpha-propionate; Cortexolone 17α-propionate; CB-03-01)

Cat. No.: HY-13331 Purity: 98.76%
Handling Instructions

Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.

For research use only. We do not sell to patients.

Clascoterone Chemical Structure

Clascoterone Chemical Structure

CAS No. : 19608-29-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg USD 780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.

IC50 & Target

Androgen Receptor[1].

In Vivo

Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

Clinical Trial
Molecular Weight

402.52

Formula

C₂₄H₃₄O₅

CAS No.

19608-29-8

SMILES

O=C1CC[[email protected]@]2(C)C(CC[[email protected]]3([H])[[email protected]]2([H])CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]@]4(C(CO)=O)OC(CC)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (248.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4843 mL 12.4217 mL 24.8435 mL
5 mM 0.4969 mL 2.4843 mL 4.9687 mL
10 mM 0.2484 mL 1.2422 mL 2.4843 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (6.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.76%

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Keywords:

ClascoteroneCortexolone 17 alpha-propionateCortexolone 17α-propionateCB-03-01Androgen ReceptorInhibitorinhibitorinhibit

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Product Name:
Clascoterone
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HY-13331
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