2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. CycLuc1

CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging.

For research use only. We do not sell to patients.

CAS No. : 1247879-16-8

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

CycLuc1 Related Antibodies

Top Publications Citing Use of Products
Bio/Physico-chemical Assay
In Vivo Imaging

    CycLuc1 purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2024 Sep 17:e0082824.  [Abstract]

    The luminescence signals of the ATCC 17978-Luc strain with CycLuc1 (10 μM) was 9.0 × 105 RLU.

    CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

    CycLuc1 (5 mM, 10 μL/g) greatly increased oFluc signals through the skull in CAG-oFluc mice by approximately 5.4-fold over D-luciferin.

    CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

    CycLuc1 (5 mM, 10 μL/g) injection improved signal detection in the head in CAG-LSL-oFluc mice.

    CycLuc1 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Apr 29.

    RLU of the tissue extracts of oFluc from C57BL/6 mice supplemented with CycLuc1 (1 mM).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging[1][2].

    IC50 & Target

    Luciferase[1]
    In Vivo

    CycLuc1 (0.05-5 mM, intraperitoneally injected) can improve bioluminescence imaging (BLI) of the existing luciferase reporter protein in mice and achieve brain imaging that D-luciferin cannot achieve[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mouse xenograft tumor models[2]
    Dosage: 0.05, 0.5, 1, 5 mM, 100 μL
    Administration: i.p.
    Result: Yielded a >10-fold higher bioluminescent signal than could be obtained from D-luciferin injection at equivalent doses.
    Molecular Weight

    305.38

    Formula

    C13H11N3O2S2
    CAS No.
    Appearance

    Solid

    Color

    Yellow to brown

    SMILES

    O=C([C@@H]1N=C(C2=NC3=CC4=C(NCC4)C=C3S2)SC1)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (163.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2746 mL 16.3730 mL 32.7461 mL
    5 mM 0.6549 mL 3.2746 mL 6.5492 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.72%

    SDS (393 KB)

    COA (248 KB) HNMR (275 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2746 mL 16.3730 mL 32.7461 mL 81.8652 mL
    5 mM 0.6549 mL 3.2746 mL 6.5492 mL 16.3730 mL
    10 mM 0.3275 mL 1.6373 mL 3.2746 mL 8.1865 mL
    15 mM 0.2183 mL 1.0915 mL 2.1831 mL 5.4577 mL
    20 mM 0.1637 mL 0.8187 mL 1.6373 mL 4.0933 mL
    25 mM 0.1310 mL 0.6549 mL 1.3098 mL 3.2746 mL
    30 mM 0.1092 mL 0.5458 mL 1.0915 mL 2.7288 mL
    40 mM 0.0819 mL 0.4093 mL 0.8187 mL 2.0466 mL
    50 mM 0.0655 mL 0.3275 mL 0.6549 mL 1.6373 mL
    60 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3644 mL
    80 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
    100 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.8187 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    CycLuc1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CycLuc11247879-16-8CycLuc 1CycLuc-1Reactive Oxygen Species (ROS)D-luciferinNIRBioluminescence imagingInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    CycLuc1
    Cat. No.:
    HY-111653
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.