Hexacosanoic acid
Based on 1 publication(s) in Google Scholar
Hexacosanoic acid is a very long-chain fatty acid. Abnormally elevated levels of Hexacosanoic acid are closely associated with various diseases, such as X-linked adrenoleukodystrophy, adrenomyeloneuropathy, atherosclerosis, and dementia.
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- Pureté: 98.15%
- CAS No.: 506-46-7
- Formule: C26H52O2
- Masse moléculaire:396.69
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hexacosanoic acid
MoreVoir tous les produits spécifiques à Isoform Endogenous Metabolite
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Activité biologique
Description
IC50 & Target
[1]|
Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
>100 μM
Compound: 32
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
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[PMID: 28911817] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats aged 2-3 weeks old[3]
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Dosage:4 mM
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Administration:Intraperitoneal injection; single dose
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Result:Significantly increased brain hexacosanoic acid levels compared to other groups.
Caused rats to present fewer crossings and rearing episodes and a higher latency to move 45 minutes after injection.
Chemical Information
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CAS No. 506-46-7
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Appearance Solid
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Masse moléculaire 396.69
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Formule C26H52O2
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Leukemia
2025 Mar;39(3):720-733. PMID: 39885295
Solvant et solubilité
In Vitro:
THF : 5.56 mg/mL (14.02 mM; Need ultrasonic)
DMSO : 5 mg/mL (12.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Yamamoto Y, et al. Chemical Synthesis of a Very Long-Chain Fatty Acid, Hexacosanoic Acid (C26:0), and the Ceramide Containing Hexacosanoic Acid. [Content Brief]
[2]. Zarrouk A, et al. Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia. J Alzheimers Dis. 2015;44(4):1349-59. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / THF | 1 mM | 2.5209 mL | 12.6043 mL | 25.2086 mL | 63.0215 mL |
| 5 mM | 0.5042 mL | 2.5209 mL | 5.0417 mL | 12.6043 mL | |
| 10 mM | 0.2521 mL | 1.2604 mL | 2.5209 mL | 6.3022 mL |
Hexacosanoic acid Related Classifications
HY-113301 Related Classifications
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