1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IACS-8968

IACS-8968 (Synonyms: IDO/TDO Inhibitor)

Cat. No.: HY-112164 Purity: 98.13%
Handling Instructions

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

For research use only. We do not sell to patients.

IACS-8968 Chemical Structure

IACS-8968 Chemical Structure

CAS No. : 2144425-14-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 629 In-stock
Estimated Time of Arrival: December 31
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 750 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

IC50 & Target

pIC50: 6.43 (IDO), <5 (TDO)[1].

Molecular Weight

381.35

Formula

C₁₇H₁₈F₃N₅O₂

CAS No.

2144425-14-7

SMILES

O=C(N1)NC2(C(C)(C)CN(C3=CC(C(F)(F)F)=CC4=CN=CN34)CC2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6223 mL 13.1113 mL 26.2226 mL
5 mM 0.5245 mL 2.6223 mL 5.2445 mL
10 mM 0.2622 mL 1.3111 mL 2.6223 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

IACS-8968IDO/TDO InhibitorIACS8968IACS 8968Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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Product Name:
IACS-8968
Cat. No.:
HY-112164
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