2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. LHC-165

LHC-165 is a TLR7 agonist. LHC-165 has potential to used in study of solid tumors.

For research use only. We do not sell to patients.

LHC-165 Chemical Structure

LHC-165 Chemical Structure

CAS No. : 1258595-14-0

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Based on 1 publication(s) in Google Scholar

LHC-165 Related Antibodies

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Description

LHC-165 is a TLR7 agonist. LHC-165 has potential to used in study of solid tumors[1][2].

IC50 & Target[1]

TLR7

 

Clinical Trial
Molecular Weight

603.55

Formula

C29H32F2N3O7P
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=C2C(C=C(CCC3=CC=C(OCCOCCC(F)(F)P(O)(O)=O)C=C3C)C=N2)=C4C(C=C(CCC(O)=O)C=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

1M NaOH : 50 mg/mL (82.84 mM; ultrasonic and adjust pH to 12 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6569 mL 8.2843 mL 16.5686 mL
5 mM 0.3314 mL 1.6569 mL 3.3137 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH 1 mM 1.6569 mL 8.2843 mL 16.5686 mL 41.4216 mL
5 mM 0.3314 mL 1.6569 mL 3.3137 mL 8.2843 mL
10 mM 0.1657 mL 0.8284 mL 1.6569 mL 4.1422 mL
15 mM 0.1105 mL 0.5523 mL 1.1046 mL 2.7614 mL
20 mM 0.0828 mL 0.4142 mL 0.8284 mL 2.0711 mL
25 mM 0.0663 mL 0.3314 mL 0.6627 mL 1.6569 mL
30 mM 0.0552 mL 0.2761 mL 0.5523 mL 1.3807 mL
40 mM 0.0414 mL 0.2071 mL 0.4142 mL 1.0355 mL
50 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8284 mL
60 mM 0.0276 mL 0.1381 mL 0.2761 mL 0.6904 mL
80 mM 0.0207 mL 0.1036 mL 0.2071 mL 0.5178 mL
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LHC-165 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LHC-1651258595-14-0LHC165LHC 165Toll-like Receptor (TLR)cancer immunotherapyTMEsolid tumourInhibitorinhibitorinhibit

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