Nosantine racemate (Synonyms: NPT 15392 racemate)

Cat. No.: HY-101687: FAQs
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Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA).

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Nosantine racemate Chemical Structure

CAS No. : 75166-67-5

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Description	Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA).
IC₅₀ & Target	IL-2^[1]
In Vitro	The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Nosantine racemate Related Antibodies
In Vivo	Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	278.35
Formula	C₁₄H₂₂N₄O₂
CAS No.	75166-67-5
SMILES	O=C1N=CNC2=C1N=CN2C(C(O)C)CCCCCC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Wiranowska-Stewart M, et al. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. Int J Immunopharmacol. 1986;8(1):63-9. [Content Brief] [2]. Exon JH, et al. The selectivity of isoprinosine, NPT 15392, avridine and cyclophosphamide on multiple immuneresponses in rats. Int J Immunopharmacol. 1986;8(1):53-62. [Content Brief]

Animal Administration
^[2]

Rats^[2]
Animals in seven of the groups are also injected subcutaneously with various dosage regimens of the immunomodulating drugs, isoprinosine (ISO), Nosantine (NPT 15392), avridine (AVD) and cyclophosphamide (CY). Individual rats in each group receive drug treatments consisting of 5 or 50 mg/kg ISO, 0.1 or 1.0 mg/kg Nosantine, 1 or 25 mg/kg AVD, or 75 mg/kg CY. Injections of ISO, Nosantine and AVD are given at three separate time intervals in relation to injection with bovine serum albumin (BSA). Isoprinosine and Nosantine are given twice at the same time as each BSA injection and a third time 3 days before termination. All rats are sacrificed by asphyxiation with CO₂ and assayed for immunocompetence 14 days after the initial BSA and KLH injections. Six separate immunoassays are performed to assess different immune responses in the same animal.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Wiranowska-Stewart M, et al. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. Int J Immunopharmacol. 1986;8(1):63-9. [Content Brief]

[2]. Exon JH, et al. The selectivity of isoprinosine, NPT 15392, avridine and cyclophosphamide on multiple immuneresponses in rats. Int J Immunopharmacol. 1986;8(1):53-62. [Content Brief]

Nosantine racemate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nosantine75166-67-5NPT 15392NPT15392NPT-15392Interleukin RelatedILInhibitorinhibitorinhibit

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Nosantine racemate (Synonyms: NPT 15392 racemate)

Nosantine racemate Related Antibodies

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