Oxadiazon
Based on 1 Customer Validation
Oxadiazon is an orally active herbicide. Oxadiazon reduces hepatic cytochrome P450 levels. Oxadiazon increases palmitoyl CoA oxidase, acetyl carnitine transferase, and hepatic ALAS activity. Oxadiazon induces hepatomegaly and experimental porphyria. Oxadiazon controls weeds. Oxadiazon may be used in neurodegenerative disease research.
For research use only. We do not sell to patients.
- Purity: 98.51%
- CAS No.: 19666-30-9
- Formula: C15H18Cl2N2O3
- Molecular Weight:345.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Oxadiazon (7.81 μM; 1-24 h) inhibits ALDH2 expression/activity, increases ACYP2 expression/activity and FGF2/BDNF-induced neuronal differentiation of human striatal precursor (HSP) cells[3].
Oxadiazon (2.5-100 μM; 72 h) induces dose-dependent increases in palmitoyl CoA oxidase and acetyl carnitine transferase activities in rat hepatocytes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Oxadiazon (20-500 mg/kg body wt/day; p.o.; once daily; 14 days) induces dose-dependent hepatomegaly, peroxisome proliferation, and increased peroxisomal enzyme activities in male Sprague-Dawley CD rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ICR mice (35 g)[4]
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Dosage:1000 ppm
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Administration:Oral administration via diet, 6 days
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Result:Increased relative liver weight to 11.2% (vs. 6.2% in control).
Increased liver porphyrin content; increased fecal porphyrin from 30.2 to 1673.1 nmol/g dry weight; increased bile porphyrin from 5.7 to 439.0 nmol/g wet weight.
Elevated PBG concentrations in liver (89 nmol/g wet weight), kidney (53 nmol/g wet weight).
Increased hepatic ALAS activity to 474 nmol ALA/g/hr.
Chemical Information
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CAS No. 19666-30-9
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Appearance Solid
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Molecular Weight 345.22
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Formula C15H18Cl2N2O3
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Color Light yellow to yellow
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SMILES
O=C1OC(C(C)(C)C)=NN1C2=CC(OC(C)C)=C(Cl)C=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : ≥ 50 mg/mL (144.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.24 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.24 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
References
[3]. Degl'Innocenti D, et al. Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells: A possible role in neurotoxicity. Toxicology. 2019 Jan 1;411:110-121. [Content Brief]
[5]. Richert L, et al. Comparison of the induction of hepatic peroxisome proliferation by the herbicide oxadiazon in vivo in rats, mice, and dogs and in vitro in rat and human hepatocytes. Toxicol Appl Pharmacol. 1996 Nov;141(1):35-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8967 mL | 14.4835 mL | 28.9670 mL | 72.4176 mL |
| 5 mM | 0.5793 mL | 2.8967 mL | 5.7934 mL | 14.4835 mL | |
| 10 mM | 0.2897 mL | 1.4484 mL | 2.8967 mL | 7.2418 mL | |
| 15 mM | 0.1931 mL | 0.9656 mL | 1.9311 mL | 4.8278 mL | |
| 20 mM | 0.1448 mL | 0.7242 mL | 1.4484 mL | 3.6209 mL | |
| 25 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 30 mM | 0.0966 mL | 0.4828 mL | 0.9656 mL | 2.4139 mL | |
| 40 mM | 0.0724 mL | 0.3621 mL | 0.7242 mL | 1.8104 mL | |
| 50 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4484 mL | |
| 60 mM | 0.0483 mL | 0.2414 mL | 0.4828 mL | 1.2070 mL | |
| 80 mM | 0.0362 mL | 0.1810 mL | 0.3621 mL | 0.9052 mL | |
| 100 mM | 0.0290 mL | 0.1448 mL | 0.2897 mL | 0.7242 mL |
Oxadiazon Related Classifications
HY-B1880 Related Classifications
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