1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-05241328

PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.

For research use only. We do not sell to patients.

PF-05241328 Chemical Structure

PF-05241328 Chemical Structure

CAS No. : 1387633-03-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 341 In-stock
Solution
10 mM * 1 mL in DMSO USD 341 In-stock
Solid
5 mg USD 310 In-stock
10 mg USD 480 In-stock
25 mg USD 850 In-stock
50 mg USD 1350 In-stock
100 mg USD 2160 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.

IC50 & Target

IC50: 31 nM (Nav1.7)[1].

Clinical Trial
Molecular Weight

436.91

Formula

C19H21ClN4O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(N(C3=CC(Cl)=C(OCC(C)C)N=C3)N=C2C)C=C1)NS(=O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (228.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2888 mL 11.4440 mL 22.8880 mL
5 mM 0.4578 mL 2.2888 mL 4.5776 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2888 mL 11.4440 mL 22.8880 mL 57.2200 mL
5 mM 0.4578 mL 2.2888 mL 4.5776 mL 11.4440 mL
10 mM 0.2289 mL 1.1444 mL 2.2888 mL 5.7220 mL
15 mM 0.1526 mL 0.7629 mL 1.5259 mL 3.8147 mL
20 mM 0.1144 mL 0.5722 mL 1.1444 mL 2.8610 mL
25 mM 0.0916 mL 0.4578 mL 0.9155 mL 2.2888 mL
30 mM 0.0763 mL 0.3815 mL 0.7629 mL 1.9073 mL
40 mM 0.0572 mL 0.2861 mL 0.5722 mL 1.4305 mL
50 mM 0.0458 mL 0.2289 mL 0.4578 mL 1.1444 mL
60 mM 0.0381 mL 0.1907 mL 0.3815 mL 0.9537 mL
80 mM 0.0286 mL 0.1431 mL 0.2861 mL 0.7153 mL
100 mM 0.0229 mL 0.1144 mL 0.2289 mL 0.5722 mL
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PF-05241328 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PF-05241328
Cat. No.:
HY-103623
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