Infection

Casimiroin is a QR2 and Aromatase inhibitor, with an IC₅₀ of 54.1 μM against QR2 and an IC₅₀ of 3.92 μM against aromatase. Casimiroin exhibits antimutagenic activity and inhibits DMBA (HY-W011845)-induced mutations in Salmonella typhimurium. Casimiroin suppresses DMBA-induced precancerous lesions in mouse mammary organ cultures. Casimiroin can be used in breast cancer-related research.

SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.

OvCHT1-IN-1 (compound 3i) is a potent OvCHT1 inhibitor with IC₅₀ of 0.6 μM .

Arborcandin D is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC₅₀ values of 3 μg/mL and 0.35 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida.

CK0492B is a novel biaminourea antibiotic that has antiplaque properties in vitro and has shown efficacy in an experimental mouse dental disease model. A 12-week study in beagles compared its efficacy in reducing plaque and gingivitis, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease are similar to humans. Chlorhexidine acetate was selected as a positive control for plaque and gingivitis reduction and staining because it is effective in both humans and dogs.

STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC₅₀ = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.

Elopiprazole can be used in study of neurological disease and SARS-CoV-2.

3'-NH-Tr-2',3'-dT-5'-CE-Phosphoramidite is a special phosphoramidite compound used in the synthesis of oligonucleotides and nucleic acid analogs. 3'-NH-Tr-2',3'-dT-5'-CE-Phosphoramidite can be used in antiviral and anticancer research.

ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi.

PLpro-IN-5 (compound 21) is a PLPro protease inhibitor with an IC₅₀ value of 91.14 nM. PLpro-IN-5 shows broad-spectrum antivirus, especially for SARS-CoV, MERS-CoV, SARS-CoV-2.

Netzahualcoyone is a triterpenoid compound isolated from the Celastraceae plant family. Netzahualcoyone exhibits broad-spectrum antibiotic activity against Gram-positive bacteria and yeasts, but is not active against Gram-negative bacteria. Netzahualcoyone can be utilized in the development of antibiotics and for studying antimicrobial mechanisms.

SARS-CoV-2-IN-96 (compound 12b) is an inhibitor of HCoV-OC43 (EC₅₀= 97 nM) and SARS-CoV-2 (EC₅₀= 45 nM) and low cytotoxicity (CC₅₀> 10 μM) in Huh7 cells.

Antifungal agent 109 (compound F) is a spirothiazolidinone compound with antifungal activity, with an inhibition zone of 10-17 mm.

FL-166 is a SARS coronavirus main protease (Mpro) inhibitor (K_i: 40 nM). FL-166 exerts its inhibitory effect by targeting a cluster of serine residues near the active site of the protease. FL-166 can be used in the study of SARS-CoV.

DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity.

Fumitremorgin B-¹³C₂₇ is the ¹³C-labeled Fumitremorgin B (HY-117313). Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.

iDeg-6 is a molecular glue degrader that selectively targets IDO1, with a DC₅₀ of 6.5 nM, an IC₅₀ of 16 nM, and a K_d of 1.46 μM. iDeg-6 competes to bind the heme-binding site of apoprotein IDO1, promoting CRL2^KLHDC3-mediated polyubiquitination of IDO1 and neddylation-modification-dependent proteasomal degradation. iDeg-6 reduces kynurenine production, abrogates the non-enzymatic pro-tumor migration function of IDO1, and inhibits tumor growth in immunodeficient mice. iDeg-6 can be used in studies of cancer, infection, and neurological diseases (such as melanoma).

HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease.

JNJ-7950 (compound 5c) exhibits antiviral activity against RSV with an EC₅₀ value of 0.78 nM. JNJ-7950 can be used in the study of respiratory tract infections.

Eukovoside is a cinnamic acid derivative found in Euphrasia regelii with anti-inflammatory, antioxidant, antibacterial, antiallergic, and antihistamine activity. Eukovoside can be used for the research of hyperglycemic diseases, eye inflammation, upper respiratory passages inflammation, hay fever, conjunctivitis, colds, influenza, sinusitis.