Infection

Lavanducyanin (WS-9659 A) is an antibiotic targeting microbial cell membranes. Lavanducyanin is promising for research of infections and cancer adjuvants.

Mandelonitrile benzoate is a defensive secretion of millipedes that releases other chemicals during the cyanidation process in addition to hydrocyanic acid (HCN) and benzaldehyde. Several families of millipedes, including Polydesmidae, Paradoxosomatidae, and Euryuridae, have been shown to secrete phenols and guaiaeol, with one Paradoxosomatid also producing ethylbenzoic acid and benzoic acid. In addition, members of the Xystodesmidae family commonly produce three compounds: benzoic acid, mandelonitrile benzoate, and benzoyl cyanide. Benzoyl cyanide has not been previously discovered as a natural product. These additional natural products are discussed as defensive antipredator and antibiotic agents. Benzoyl cyanide appears to have anesthetic properties for some predators. The study provides a preliminary chemotaxonomic basis for distinguishing various taxonomic groups of millipedes.

FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)_[1].

Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CL^pro activity.

Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/mL, respectively.

Protein kinase G inhibitor-2 (Compound 266) is a mycobacterial protein kinase G inhibitor, with an IC₅₀ of 3 μM. Protein kinase G inhibitor-2 can be used for mycobacterial infection research.

Sclareolide (Standard) is the analytical standard of Sclareolide. This product is intended for research and analytical applications. Sclareolide is isolated from the flower of Perilla frutescens with antibacterial and cytotoxic activities[1].

Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 μM and 2.6 μM, respectively.

Antifungal agent 13 exhibits remarkable antifungal activity against Sclerotinia sclerotiorum with an EC₅₀ value of 1.25 mg/L.

PDE4B-IN-7 is a PDE-4B inhibitor with an IC₅₀ of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent.

Cefpirome (HR 810) is a fourth generation cephalosporin. Cefpirome shows antibacterial activity. Cefpirome also has in vitro activity against Streptococcus pneumoniae.

Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC₅₀ values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules.

Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM).

Maximin 7 is an antimicrobial peptide derived from toad Bombina maxima.

COX-2-IN-65 is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 10.24 μM. COX-2-IN-65 inhibits Staphylococcus aureus and Escherichia coli growth. COX-2-IN-65 scavenges reactive oxygen species (ROS). COX-2-IN-65 can be used for the researches of bacterial infections and inflammation.

1-Undecanol-d₄ (Undecyl alcohol-d₄) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps.

Succinate dehydrogenase-IN-1 (Compound 34) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 0.94 μM and a K_D of 22.4 μM. Succinate dehydrogenase-IN-1 exhibits antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC₅₀ of 0.04 μM, 1.13 μM, 1.61 μM and 1.21 μM, respectively.

Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC₅₀=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC₅₀=0.125-0.25 μg/mL).

Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC₅₀ = 0.59 µM) and anti-Leishmania major amastigotes activity (IC₅₀ = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells).

Glenthmycin A is a macrocyclic type II spiroketal polyketide antibacterial agent. Glenthmycin A inhibits the growth of Gram-positive pathogens. Glenthmycin A is applicable to the research of bacterial infections.