Infection

Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µMsup>[2]sup>[3]sup>[4].

Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC₅₀ of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence.

Bombinin H1 is an antimicrobial peptide derived from the skin of moth Bombina variegata. The lethal concentrations of Bombinin H1 against Escherichia coli D21 and Staphylococcus aureus Cowan 1 are 3.8 and 2.1 μM, respectively.

Mal-Val-Cit-PABC-Dexamethasone is a conjugate of the glucocorticoid receptor agonist Dexamethasone (HY-14648) and a ADC linker, which can be used for the synthesis of antibody-drug conjugates (ADC). Mal-Val-Cit-PABC-Dexamethasone is designed to deliver immunosuppressants to monocytes and/or monocyte-derived cells in a targeted manner.

Sulfalene-¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial.

Rubiginone D2 is an antibiotic, which exhibits antimicrobial activities against Bacillus subtilis, Staphylococcus aureus and Escherichia coli. Rubiginone D2 exhibits antitumor efficacy, inhibits proliferations of cancer cells HM02, Kato III, HepG2 and MCF7, with GI₅₀s of 0.1, 0.7, <0.1 and 7.5 μM, respectively.

Antimicrobial agent-31 (compound 4a) is a potent antimicrobial agent. Antimicrobial agent-31 inhibits Salmonella enterica serovar Typhimurium and E.coli with MIC values of 19.24, 11.31 µg/mL, respectively.

Bismuth subcitrate potassium (Standard) is the analytical standard of Bismuth subcitrate potassium (HY-16102). This product is intended for research and analytical applications. Bismuth subcitrate potassium is a compound bismuth salt with oral activity. Bismuth subcitrate potassium has antibacterial activity and can inhibit the growth of Campylobacter pyloridis with a MIC₅₀ of 8 μg/mL. Bismuth subcitrate potassium can be used in the study of gastrointestinal diseases infected by Campylobacter pyloridis.

NITD-304 is an orally active anti-tuberculosis agent. NITD-304 exerts inhibitory and bactericidal activities gainst Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis. NITD-304 inhibits mycobacterial cell wall biosynthesis and demonstrates synergistic or additive growth inhibitory activity with select antibacterial agents. NITD-304 shows low risk of cardiotoxicity and drug-drug interactions, with no inhibition of major cytochrome P-450 enzymes or hERG channel. NITD-304 can be used for the research of tuberculosis and multidrug-resistant tuberculosis.

Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

Smallanthus sonchifolius extract (Yacon extract) is an extract of yacon (Smallanthus sonchifolius) that has antibacterial, hypoglycemic, anti-obesity, anti-cancer, and cholesterol-lowering activities.

Cy3 labled Daplusiran sodium is a Cy3 labled Daplusiran sodium.

RyRs activator 2 (compound 7o) is a potent activator of ryanodine receptors (RyRs). RyRs activator 2 is 30% larvicidal activity, comparable to chlorantraniliprole (30%) and better than cyantraniliprole (10%).

Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes.

20S Proteasome-IN-6 is a species-selective inhibitor of the Mycobacterium tuberculosis 20S proteasome. 20S Proteasome-IN-6 penetrates the Mycobacterium tuberculosis bacilli, sensitizes the bacteria to nitrosative stress, and reduces the bacterial burden of live Mycobacterium tuberculosis within infected macrophages. 20S Proteasome-IN-6 can be used for tuberculosis research.

Lasalocid (Standard) is the analytical standard of Lasalocid. This product is intended for research and analytical applications. Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent that can be used as feed additives. Lasalocid exhibits antitumor activity. Lasalocid is orally active.

Ianthelliformisamine C ditrifluoroacetate is an antibiotic enhancer with activity against resistant Gram-negative bacteria. Ianthelliformisamine C ditrifluoroacetate has been shown to improve the efficacy of doxycycline against Pseudomonas aeruginosa. Ianthelliformisamine C ditrifluoroacetate was prepared using peptide coupling, resulting in high chemical yields of 27 to 91%. Ianthelliformisamine C ditrifluoroacetate exhibits its mechanism of action by inducing ATP efflux and causing membrane depolarization in bacterial cells.

BET-IN-8 (Compound 27) is a potent inhibitor of BET with a K_i and K_d of 0.83 and 0.571 μM, respectively. BET-IN-8 ameliorates LPS-induced sepsis in vivo. BET-IN-8 has the potential for the research of sepsis.

CKP-25 is an inhibitor for the interaction between Spike RBD-ACE2, that prevents the virus from entering the host cell, thereby reducing the replication and virus infection. CKP-25 inhibits SARS-CoV-2 with IC₅₀ of 3.5 μM in Vero E6 cell.

TRX585 is a humanised anti-immunoglobulin-like transcript 5 (ILT5) monoclonal antibody. TRX585 has a potent immunoregulatory activity. TRX585 significantly activates human T cells and upregulates NKG2D and Fas ligand, followed by enhancing antitumor activity with potent cytotoxicity. TRX585 can be used for viral infections and malignancies research.