Infection

SPSB2-iNOS inhibitory cyclic peptide-3 (Compound CP3) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM.

BDGR-651 is an efficient and selective inhibitor of the Chikungunya virus (CHIKV) with an EC₅₀ in NHDF cells of 0.86 μM, and the therapeutic index (SI) of 22.1. BDGR-651 exhibits dose-dependent protective effects when infecting Vero E6 cells, with its EC₅₀ being 6 μM. BDGR-651 can be used for research on CHIKV infection.

HIV-1 integrase inhibitor 11 (compound 5) is a potent inhibitor of HIV-1 integrase, with the IC₅₀ of 125 μM.

Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively.

Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.

Antiviral agent 41 (compound 5) is a diarylheptanoid isolated from Alpinia officinarum. Antiviral agent 41 exhibits potential antiviral activity against influenza virus in vitro.

SARS-CoV-2-IN-29 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-29 disodium exhibits antiviral activity with IC₅₀s of 1.5 μM and 1.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-29 disodium induces liposomal membrane disruption with an EC₅₀ value of 3.0 μM.

6-Hydroxytropinone (Standard) is the analytical standard of 6-Hydroxytropinone. This product is intended for research and analytical applications. 6-Hydroxytropinone is a Alkaloids product that can be isolated from the roots of Atropa belladonna.

4-epi-Chlortetracycline hydrochloride is an epimetabolite of Chlortetracycline hydrochloride. Chlortetracycline hydrochloride is an orally active, potent and selective inhibitor of methanogenic bacteria with bactericidal effect.

Procyanidin A2 (Standard) is the analytical standard of Procyanidin A2. This product is intended for research and analytical applications. Procyanidin A2 is a flavonoid found in grapes, with anti-cancer, antioxidant, antimicrobial and anti-inflammation activity.

SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent with anti-SARS-CoV-2 properties.

Anti-MRSA agent 5 (B14) is a potent
MRSA
agent with MIC₅₀ values of 0.38 μg/mL and has low hERG activity with an IC₅₀ values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance.

Garvicin KS, GakC is a peptide at sizes of 32 amino acids to form bacteriocin garvicin KS (GarKS), with other 2 peptides, GakA, and GakB. Garvicin KS, GakC inhibits fibroblast viability and proliferation. Garvicin KS peptides inhibit MSSA with MIC values in the order GakB >GakC >GakA.

HBV-IN-17 (compound 8) is a potent HBV capsid assembly modulator with an EC₅₀ of 511 nM.

Dihydro-N-caffeoyltyramine is a new phenolic amide that can be isolated from the root bark of wolfberry and has strong antioxidant activity and antifungal effects. Dihydro-N-caffeoyltyramine downregulates the expression of cyclooxygenase-2 by inhibiting the activity of C/EBP and AP-1 transcription factors.

SARS-CoV-2 Mpro-IN-50 (Compound 30) is a noncovalent SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 14  nM. SARS-CoV-2 Mpro-IN-50 is also a pan-CoV Mpro inhibitor with IC₅₀ s of 20-190 nM for SARS-CoV-1 Mpro, 229E Mpro, HKU1 Mpro, MERS Mpro, NL63 Mpro and OC43 Mpro. SARS-CoV-2 Mpro-IN-50 has significant antiviral activity against the SARS-CoV-2 omicron variant (EC₅₀ : 22  nM). SARS-CoV-2 Mpro-IN-50 can be used for coronavirus infections research.

Drechslerine A has neuraminidase inhibitory activity (IC₅₀: 0.79 μM). Drechslerine A is a terpene that can be isolated from endophytic Cochliobolus. Drechslerine A can be used for research of Influenza Virus.

Acronycidine is a quinoline alkaloid with antimalarial activity and can be extracted from Acronychia baueri Schott. Acronycidine can be utilized in malari research.

Antibacterial agent 362 is a broad-spectrum antibacterial agent. Antibacterial agent 362 exhibits broad-spectrum inhibitory activity against a variety of mycobacteria and Staphylococcus aureus, with a MIC₅₀ of 235 μM against M. tuberculosis, while it shows no activity against Escherichia coli. Antibacterial agent 362 can be used in research related to tuberculosis and mycobacterial infections.

Artemisinin-¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.