2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101593
    Fibracillin 51154-48-4 98%
    Fibracillin is a penicillin antibiotic.
    Fibracillin
  • HY-101651
    WQ 2743 189280-13-5 98%
    WQ 2743 is a potent antimicrobial agent.
    WQ 2743
  • HY-10165R
    PSI-6130 (Standard) 817204-33-4 98%
    PSI-6130 (Standard) is the analytical standard of PSI-6130 (HY-10165). This product is intended for research and analytical applications. PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM.
    PSI-6130 (Standard)
  • HY-101739
    Amcinafal 3924-70-7 98%
    Amcinafal is an active diol, used against virus replication and interferon production.
    Amcinafal
  • HY-101818
    PNU288034 383199-88-0 98%
    PNU288034 is a potent oxazolidinone antibiotic.
    PNU288034
  • HY-101967
    GSK299423 1352149-24-6 98%
    GSK 299423 is an antibiotic agent.GSK299423 shows potent inhibition of supercoiling by DNA gyrase from S. aureus(IC50=14 nM）and Escherichia coli(IC50=100 nM.
    GSK299423
  • HY-102008
    LBM-415 478913-91-6 98%
    LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC90 range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy.
    LBM-415
  • HY-102072
    GKL003 1445801-61-5 98%
    GKL003 is a bacterial transcription inhibitor that targets the RNAP-σ interaction interface, with a Ki of 5.79 nM. GKL003 specifically binds to the RNAP β' clamp helix region at the σA factor binding site, blocks the formation of RNAP holoenzyme, and inhibits the formation of bacterial transcription initiation complexes. GKL003 inhibits the growth of both Gram-positive and Gram-negative bacterial cells, and also exhibits activity against drug-resistant strains.
    GKL003
  • HY-10234S
    Saracatinib-d3 2200301-36-4 98%
    Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the Src kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections.
    Saracatinib-d3
  • HY-10237R
    Boceprevir (Standard) 394730-60-0 98%
    Boceprevir (Standard) is the analytical standard of Boceprevir. This product is intended for research and analytical applications. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay. Boceprevir inhibits SARS-CoV-2 3CLpro activity.
    Boceprevir (Standard)
  • HY-10238R
    Danoprevir (Standard) 850876-88-9 98%
    Danoprevir (Standard) is the analytical standard of Danoprevir (HY-10238). This product is intended for research and analytical applications. Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM). Danoprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 0.05 μM.
    Danoprevir (Standard)
  • HY-10240R
    Mericitabine (Standard) 940908-79-2
    Mericitabine (Standard) is the analytical standard of Mericitabine. This product is intended for research and analytical applications. Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
    Mericitabine (Standard)
  • HY-10241R
    Simeprevir (Standard) 923604-59-5 98%
    Simeprevir (Standard) is the analytical standard of Simeprevir (HY-10241). This product is intended for research and analytical applications. Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.
    Simeprevir (Standard)
  • HY-10244R
    MK-0608 (Standard) 443642-29-3 98%
    MK-0608 (Standard) is the analytical standard of MK-0608 (HY-10244). This product is intended for research and analytical applications. MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.
    MK-0608 (Standard)
  • HY-10300R
    Narlaprevir (Standard) 865466-24-6 98%
    Narlaprevir (Standard) is the analytical standard of Narlaprevir. This product is intended for research and analytical applications. Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM.
    Narlaprevir (Standard)
  • HY-103031
    GSK 124576A 1443139-14-7 98%
    GSK 124576A (compound 8) is a Mycobacterium tuberculosis cytochrome bc1 complex inhibitor and member of the 2-(quinolin-4-yloxy)acetamide class. GSK 124576A can be used for the research of tuberculosis.
    GSK 124576A
  • HY-10353R
    Raltegravir (Standard) 518048-05-0 98%
    Raltegravir (Standard) is the analytical standard of Raltegravir (HY-10353). This product is intended for research and analytical applications. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
    Raltegravir (Standard)
  • HY-10367R
    Canertinib (Standard) 267243-28-7 98%
    Canertinib (Standard) is the analytical standard of Canertinib. This product is intended for research and analytical applications. Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice.
    Canertinib (Standard)
  • HY-10373R
    Trimetrexate (Standard) 52128-35-5 98%
    Trimetrexate (Standard) is the analytical standard of Trimetrexate (HY-10373). This product is intended for research and analytical applications. Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
    Trimetrexate (Standard)
  • HY-10392S
    Sutezolid-13C4 98%
    Sutezolid-13C4 (PNU-100480-13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis.
    Sutezolid-13C4
Cat. No. Product Name / Synonyms Application Reactivity