Infection

Topoisomerase inhibitor 5 (compound 158) is a Bacterial Topoisomerase Inhibitor inhibitor with the lowest inhibitory concentration of 0.125 μg/mL. Topoisomerase inhibitor has antituberculous activity.

MPS-Gαi2 is a membrane-permeable inhibitory peptide corresponding to the C-terminal sequence of Gαi2 involved in receptor interaction. MPS-Gαi2 blocks Hep I-induced binding of Gαi2 to LRP, thereby inhibiting pertussis toxin-sensitive Gαi2 signaling and focal adhesion disassembly mediated by thrombospondin/Hep I-calreticulin-LRP. MPS-Gαi2 can be used in studies on G protein signaling and cell adhesion regulation.

SARS-CoV-2-IN-33 (compound 3m) is a COVID-19 inhibitor. SARS-CoV-2-IN-33 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-33 exhibits comparatively good binding affinity (-8.0 Kcal/mole) to COVID-19 main protease (M^pro) (PDB ID: 6LU7). SARS-CoV-2-IN-33 can be used in studies of cancer and COVID-19.

Myrrhterpenoid O (Compound 18) is a sesquiterpenoid compound that exhibits good inhibitory activity against Plasmodium falciparum (IC₅₀ = 21 μM).

PROTAC ACC degrader-1 is an Acetyl-CoA Carboxylase PROTAC degrader with insecticidal activity, which induces ACC protein degradation via the ubiquitin-proteasome system. PROTAC ACC degrader-1 exhibits significant dose-dependent insecticidal activity against Aphis craccivora nymphs. PROTAC ACC degrader-1 can be used in studies related to Aphis craccivora infestation.

Mixture of Aflatoxins in Acetonitrile (Standard) is mainly used for the detection of aflatoxins in grain, oils, foods and traditional Chinese medicines.

Vicriviroc (SCH 417690) malate is an orally active CCR5 antagonist with the IC₅₀ of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC₅₀ values of 0.91 nM and 16 nM,,respectively. Vicriviroc malate can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer.

Temephos-d₁₂ is the deuterium labeled Temephos. Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis.

Anti-Influenza agent 4 is a potent and selective influenza virus inhibitor with EC₅₀s of 150 nM and 62 nM for strains A/Roma and A/Parma, respectively.

SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M^pro with an IC₅₀ value of 72.07 nM. The main protease (M^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19.

Alahopcin is a dipeptide antibiotic with a broad antibacterial spectrum.

TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity.

14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-2 has antimicrobial activities.

KNI-102 is a potent anti-HIV agent with an IC₅₀ value of 100 nM for HIV protease.

PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na⁺, K⁺-ATPase.

Methyl O-methylpodocarpate is an influenza A virus (H1N1) inhibitor with activity against H1N1 strains resistant to Oseltamivir and Amantadine, with an EC₅₀ of 0.73 μM. Methyl O-methylpodocarpate blocks viral membrane fusion by targeting hemagglutinin (HA). Methyl O-methylpodocarpate shows only weak activity against the H3N2 subtype and exhibits no significant cytotoxicity to MDCK cells. Methyl O-methylpodocarpate can be used in studies related to H1N1 infection.

Chloramphenicol palmitate (Standard) is the analytical standard of Chloramphenicol palmitate (HY-B1599). This product is intended for research and analytical applications. Chloramphenicol palmitate is an orally active prodrug of Chloramphenicol (HY-B0239), obtained from the esterification reaction between the agent and Palmitic acid (HY-N0830). Chloramphenicol palmitate is rapidly and completely hydrolyzed by intestinal esterase, releasing Chloramphenicol. Chloramphenicol is an orally effective broad-spectrum antibiotic.

Antileishmanial agent-40 is an orally active and selective antileishmanial agent. Antileishmanial agent-40 elevates intracellular reactive oxygen species (ROS) levels in Leishmania donovani promastigotes. Antileishmanial agent-40 induces cell cycle arrest at the sub-G₀/G₁ phase in Leishmania donovani promastigotes, indicative of programmed-like parasite death. Antileishmanial agent-40 can be used for the research of leishmaniasis.

Iodopropynyl butylcarbamate-d₉ (IPBC-d₉) is the deuterated-labeled Iodopropynyl butylcarbamate (HY-W009335). Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum antibacterial agent. Iodopropynyl butylcarbamate disrupts bacterial membranes and inhibits V. parahaemolyticus and S. aureus biofilms. Iodopropynyl butylcarbamate exhibits antimold activity and displays broad-spectrum antifungal/antialgal activity involving iodine-thiol protein disruption. Iodopropynyl butylcarbamate can be used in research related to bacterial and fungal infections.

Hydroxymetronidazole (Standard) is the analytical standard of Hydroxymetronidazole. This product is intended for research and analytical applications. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.