Infection

11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.

Ro 13-3978 is an orally active antischistosomal agent. Ro 13-3978 exhibits excellent in vivo antischistosomal activity against juvenile and adult Schistosoma mansoni infections. Ro 13-3978 shows no in vivo activity against E. caproni and F. hepatica. Ro 13-3978 blocks dihydrotestosterone-induced proliferation of androgen-dependent cells. Ro 13-3978 can be used in research related to schistosomiasis.

α-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC₅₀ of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections.

Hexachloroparaxylene could be used in the study of in fascioliasis in swine.

Suc-AAPE-pNA is a chromogenic substrate of glutamyl endopeptidase. Suc-AAPE-pNA can be used to test glutamyl endopeptidase activity.

3-O-Debenzoylzeylenone is a polyoxygenated cyclohexene plant growth hormone that exists in the leaves of Uvaria purpurea and the aerial parts of Uvaria grandiflora. 3-O-Debenzoylzeylenone is an auxin analog that inhibits root growth and promotes shoot growth of Lactuca sativa seedlings. 3-O-Debenzoylzeylenone exhibits cytotoxicity against various cancer cells and can be used in studies related to lung cancer, melanoma, epidermoid carcinoma, liver cancer, gastric cancer, colon adenocarcinoma, acute leukemia, breast cancer, and prostate cancer.

T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC₅₀ of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC₅₀ of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC₅₀ of 18.38 μM.

Cymbopogon citratus extract (Cymbopogon titrtus extract) is a lemongrass (Cymbopogon Citratus DC (Stapf.)) extract with antibacterial, antiprotozoal, antirheumatic, antitumor, cardioprotective, anti-inflammatory and gastric protective properties.

Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

Cefuracetime (Standard) (SKF81367 (Standard)) is the analytical standard of Cefuracetime (HY-U00154). This product is intended for research and analytical applications. Cefuracetime is a cephalosporin antibiotic.

Fleroxacin (Standard) is the analytical standard of Fleroxacin. This product is intended for research and analytical applications. Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone.

Amycolatopsin B (compound 2) is a glycosylated polyketide macrolide with antifungal activity that was isolated from the soil isolate Amycolatopsis sp. MST-108494.

Antibacterial agent 352 is an orally active Antibacterial agent. Antibacterial agent 352 binds to the active cavity of Staphylococcus aureus DNA gyrase via hydrogen bonding, π-π stacking and hydrophobic interactions, thereby blocking bacterial DNA synthesis. Antibacterial agent 352 exhibits antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus pumilus, Staphylococcus epidermidis and Enterococcus faecalis. Antibacterial agent 352 can disrupt established Staphylococcus aureus biofilms and inhibit the formation of Staphylococcus aureus biofilms. Antibacterial agent 352 can be used in the research of Staphylococcus aureus wound infections.

(E)-4-Methyl-5-styrylbenzene-1,3-diol (Compound III) is an antifungal agent and can be extracted from Dracaena cochinchinensis (Lour.) S. C. Chen.

SARS-CoV-2-IN-68 (compound 6C) is a covalent SARS-CoV-2 PLpro/Mpro inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro.

MurA-IN-7 (Compound 9) is a reversible MurA covalent inhibitor with an IC₅₀ value of 164 μM. MurA-IN-7 can be used in antibacterial research.

Chrymutasin A is a glycosidic antitumor antibiotic. Chrymutasin A is cytotoxic.

Dechlorogriseofulvin (7-Dechlorogriseofulvin) is an antibiotic, and exhibits inhibitory activity against various plant pathogenic fungi. Dechlorogriseofulvin inhibits Botrytis cinerea, Rhizoctonia solani, Pythium ultimum, and Sclerotinia sclerotiorum with MIC of 40.0 µg/ml, 43.9 µg/ml, 81.7 µg/ml, and 28.5 µg/ml, respectively.

Tricyclazole (Standard) is the analytical standard of Tricyclazole. This product is intended for research and analytical applications. Tricyclazole is a pentaketide-derived melanin biosynthesis inhibitor and a unique fungicide for control of Pyricularia oryzae on rice.

Anti-Trypanosoma cruzi agent-5 (compoung 8) is a potent inhibitor of Trypanosoma cruzi proliferation.