Infection

2-Hydroxybutirosin is an antibiotic found in Bacillus circulans.

Cyperine is a phytotoxic fungal metabolite that has been found in A. cypericola. It inhibits A. thaliana enoyl-acyl carrier protein reductase (ENR; IC₅₀=89 μM). Cyperine induces necrosis in a panel of nine plant species in a leaf bioassay and inhibits root growth in A. thaliana seedlings (IC₅₀=38.4 μM).

Oganomycin GB is Streptomyces str. oganonensis Y-G 19Z and Oganomycin A is produced when p-hydroxycinnamate sodium salt is added to the fermentation medium. Under the action of D-amino acid oxidase, A generates glutaryl derivative, GA; A and GA were converted to B and GB by acid hydrolysis to remove sulfate esters. The effect of B on d-amino acid oxidase was also changed to GB. A and B were more stable than A and B of cemycin, and had stronger effect against Gram-positive and Gram-negative bacteria than Gram-positive bacteria. The antibacterial activity of A and B was higher than that of GA and GB.

Emerin is an antibiotic found in the strain of Aspergillus nidulans.

DSM267 is a triazolopyrimidine inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), with an IC₅₀ of 38 nM, while its IC₅₀ against human DHODH exceeds 100000 nM. DSM267 is used for the in vitro systematic screening and characterization of the resistance evolution pathways of Plasmodium falciparum to DHODH inhibitors.

2-Deoxy-20-hydroxyecdysone is an ecdysteroid. 2-Deoxy-20-hydroxyecdyson can be isolated from zoanthid Zoanthus sp.. 2-Deoxy-20-hydroxyecdysone exhibits lower moulting hormone activity than 20-hydroxyecdysone in Musca bioassays.

Bictegravir-d₇ (GS-9883-d₇) is deuterium labeled Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM.

AAK1-IN-7 (Compound 16) is a dual AAK1/GAK inhibitor (EC₅₀ values are 40 and 80 nM, respectively). AAK1-IN-7 inhibits the phosphorylation of AP2-µ2 subunit at T156. AAK1-IN-7 has weak antiviral activity against RNA viruses.

9-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candida albicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect.

Cephalomycin B showes weak activity against Gram-positive and negative bacteria.

(E)-Cefodizime ((E)-THR-221) is an antibiotic. (E)-Cefodizime can selectively bind to penicillin-binding proteins (PBPs) and inhibit the synthesis of the bacterial cell wall, thereby exerting antibacterial activity. (E)-Cefodizime is promising for research of various bacterial infectious diseases, such as for preoperative infection prophylaxis.

Oseltamivir impurity-1 (Page 2, Row 4, Column 3), a carboxylic acid derivative, is an impurity of Oseltamivir (HY-13317). Oseltamivir impurity-1 shows antiviral effect on multiple influenza virus strains.

N-0159 is a type II transmembrane serine protease (TTSP) inhibitor with anti-influenza virus activity. N-0159 exhibits a K_i of 0.06 nM against matriptase and acts through competitive and reversible inhibition of matriptase catalytic activity. N-0159 inhibits H1N1 influenza virus replication in human bronchial epithelial cells (IC₅₀ = 292 nM). N-0159 can be used for research related to influenza virus infection.

Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections.

Favipiravir-¹³C3 is the ¹³C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

Monamycin I is an ester peptide antibiotic. Monamycin I has activity against Gram-positive bacteria.

SDH-IN-33 (Compound I-9) is a succinate dehydrogenase inhibitor. SDH-IN-33 exhibits excellent fungicidal activity with an EC₅₀ of 0.07 μg/mL. SDH-IN-33 inhibits R. solani succinate dehydrogenase (RsSDH) with an IC₅₀ 0.35 μg/mL. SDH-IN-33 can be used for the study of fungal infection.

PUN-96956 is an inhibitor of the β-barrel assembly machine (BAM) complex. By inhibiting the folding of β-barrel outer membrane proteins (OMPs) and their insertion into the outer membrane, PUN-96956 disrupts outer membrane integrity and induces the cell envelope stress response. PUN-96956 can be used in studies of bacterial infections caused by ESKAPE pathogens, uropathogenic Escherichia coli, and Gram-positive bacteria.

Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain.

HIV-IN-14 is an agent that binds to the HIV-1 reverse transcriptase p66 domain (monomeric GAG-POL), and also acts as a selective cytotoxic agent. HIV-IN-14 promotes GAG-POL dimerization, which in turn leads to premature activation of intracellular viral protease. HIV-IN-14 selectively kills HIV-infected cells expressing GAG-POL without exerting cytotoxicity on non-HIV-infected cells. HIV-IN-14 can be used in the research of HIV infection, acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC).