Metabolic Disease

Sodium 2-hydroxybutanoate is an endogenous metabolite. Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite. Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia. Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury.

Compound amino acids solution (18AA) is a nutritional supplement solution containing 18 essential and non-essential amino acids, which can improve the nutritional status.

Tmem19 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmem19 (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Tmem19 siRNA-1: 5 nmol (HPLC)
Tmem19 siRNA-2: 5 nmol (HPLC)
Tmem19 siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)

KHK-IN-8 is a selective KHK inhibitor, with an IC₅₀ of 13.0 nM against hKHK-C and an IC₅₀ of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity.

dCDP (2'-Deoxycytidine-5'-diphosphate) disodium is a monomeric raw material that can be used for nucleic acid synthesis.

Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor.

1,2-Diheptadecanoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) ((2R)-2,3-Bis(heptadecanoyloxy)propyl 2,3-dihydroxypropyl phosphate (sodium)) is an ester product.

Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism.

Sotagliflozin (Standard) is the analytical standard of Sotagliflozin. This product is intended for research and analytical applications. Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

Lauryl myristoleate is an ester product.

Pentacosanoic acid (Standard) is the analytical standard of Pentacosanoic acid. This product is intended for research and analytical applications. Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate[1].

2'-O-Propargyl-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.

Bisphenol F-¹³C₁₂ is the ¹³C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).

Maltose monohydrate (Standard) is the analytical standard of Maltose monohydrate. This product is intended for research and analytical applications. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.

7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.

6,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

Myristyl arachidonate is an ester product.

CAP m7(3'-OMeG)(5')vppp(5')(2'-OMeA)pU is a monomeric raw material that can be used for nucleic acid synthesis.

Coronaric acid methyl ester is an ester product.

Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC₅₀ <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model.