Neurological Disease

Galanin (1-29)(rat, mouse) is a non-selective galanin receptor agonist, with K_is of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively. Anticonvulsant effect.

Catechol-O-methyl Transferase, Porcine (EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine.

DAM-001 (Z236004662) is a potent, non-competitive allosteric inhibitor for human dopamine transporter (hDAT) with an IC₅₀ of 24.70 μM and 1.026 μM in the absence and presence of orthosteric inhibitor Nomifensine (HY-B1110).

KCNT1-IN-3 (Compound 31) is a KCNT1 inhibitor with an IC₅₀ value of 30 nM against the wild-type human KCNT1. KCNT1-IN-3 can be used in the research of epilepsy.

Anti-Rat CD47 Antibody (OX-101) reacts with CD47. Anti-Rat CD47 Antibody (OX-101) accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

Tamsolusin hydrochloride (YM12617 hydrochloride; LY253351 hydrochloride) is an isomer of Tamsulosin (HY-B0661). Tamsolusin hydrochloride is a sulfonamide phenethylamine derivative and a competitive antagonist of selective post-synaptic α₁-adrenoceptors. Tamsolusin hydrochloride inhibits CYP3A4 activity in a non-competitive, enantiomer-specific manner, with an IC₅₀ and K_i of 6.75 μM. Tamsolusin hydrochloride produces dose-dependent hypotension, preferentially antagonizing α₁-adrenoceptor-mediated pressor responses, and inhibits α₂-adrenoceptor-mediated pressor responses at high doses. Tamsolusin hydrochloride can be used in research related to various diseases such as metabolism.

TMR Biocytin is a polar tracer used in the research of cell-cell and cell-liposome fusions, as well as membrane permeability and cellular uptake during pinocytosis. TMR Biocytin can be detected using streptavidin, and is an effective neuronal tracer in live tissue (Ex=544 nm, Em=571 nm).

HINT1-IN-1 (Compound 8) is the inhibitor for histidine triad nucleotide-binding protein 1 (HINT1) with a K_i of 1.14 μM. HINT1-IN-1 affects the cross-regulation between μ-opioid receptor (MOR) and NMDA receptor (NMDAR). HINT1-IN-1 enhances the analgesic effect of morphine without causing opioid tolerance and has independent analgesic effects in mouse model.

MAO-B-IN-38 (Compound 6b) is a reversible and competitive MAO-B inhibitor, with IC₅₀ values of 0.03 and 21.46 µM for MAO-B and MAO-A, respectively. MAO-B-IN-38 can be used for the research of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases.

Anticonvulsant agent 11 (Compound 8b) is an anticonvulsant agent. Anticonvulsant agent 11 exerts neuroprotective effects by enhancing cell viability and reducing ROS levels. Anticonvulsant agent 11 induces the expression of GABA_A α1, resulting in neuronal hyperpolarization. Anticonvulsant agent 11 increases the number of neurite-bearing cells and the length of neurites. Anticonvulsant agent 11 exhibits dose-dependent anticonvulsant effects in mice. Anticonvulsant agent 11 can be used for the research of epilepsy.

CNI-H0294 hydrochloride is a selective HIV-1 integrase inhibitor. CNI-H0294 hydrochloride is promising for research of HIV-associated central nervous system diseases.

(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model.

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM.

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia.

R214127 is a selective mGlu1 receptor antagonist with IC₅₀ values of 6 and 14 nM for rat and human mGlu1a. R214127 acts on a site from the glutamate binding pocket, and competes for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists.

L694247 (TFA) is a selective 5-HT1D agonist with pIC₅₀ values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors, respectively.

Lanabecestat (AZD3293; LY3314814) hydrochloride is a potent BACE1 inhibitor that has been investigated for its potential as a modifying treatment for Alzheimer's disease. Lanabecestat (hydrochloride) demonstrated significant dose- and time-dependent reductions in concentrations of amyloid beta peptides in plasma, cerebrospinal fluid, and brain. Lanabecestat (hydrochloride) was also shown to produce reductions in Aβ neuritic plaque burden without demonstrating clinical benefits or slowing the progression of Alzheimer's disease pathophysiology.

GSK-3β-IN-30 is a glycogen synthase kinase-3β (GSK-3β) inhibitor. GSK-3β-IN-30 stabilizes its conformation in the binding pocket by occupying the ATP-binding cleft of GSK-3β, forming hydrogen bonds with Lys183 and Ser203, and establishing π-anion interactions with Asp181 and Asp200. GSK-3β-IN-30 can be used for the research of Alzheimer's disease.

Cbz-Pro-Leu-Gly-OH is a tripeptide that can be used in Parkinson's disease research.

EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy.