Neurological Disease

GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC₅₀=30 nM). GSK-9772 has anti-inflammatory activity by binding to LXR, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases.

SDZ NVI 085 is a compound with CNS stimulatory effects, primarily through the α1-adrenoceptor subtype, with anti-cataplexy and anti-stroke activities. SDZ NVI 085 also has a significant alertness effect and can be used to study other types of excessive sleepiness.

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine.

CP-316819 (GPi 819) Standard is the analytical standard of CP-316819 (HY-108615). This product is intended for research and analytical applications. CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes.

Gelsemine (Standard) is the analytical standard of Gelsemine. This product is intended for research and analytical applications. Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects.

2-Aminotetralin is a potent and selective serotonin 5-HT₁ agonist. 2-Aminotetralin exhibits high affinity (K_i≤25 nM) and at least 50-fold stereoselective preference at 5-HT_1A, 5-HT_1B, and 5-HT_1D receptors.

Acamprosate (calcium) (Standard) is the analytical standard of Acamprosate (calcium). This product is intended for research and analytical applications.

N,N-didesmethyl AH 7921 is structurally categorized as an opioid metabolite and is a metabolite of AH 7921.

Ucf-101 (Standard) is the analytical standard of Ucf-101. This product is intended for research and analytical applications. Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect.

A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pK_i value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade.

Nefazodone (Standard) is the analytical standard of Nefazodone. This product is intended for research and analytical applications. Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction.

PB-22 8-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.

Sofpironium bromide (Standard) is the analytical standard of Sofpironium (bromide) (HY-109013). This product is intended for research and analytical applications. Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.

Meclizine N-oxide is a metabolite of the histamine H1 receptor antagonist Meclizine (HY-B0349A).

Nitromethaqualone is a quinazolinone compound that can be used as an analytical reference standard for quinazolinones.

AChE/nAChR-IN-1 (Compound 1a) is dual-functional inhibitor of AChE and nAChR. AChE/nAChR-IN-1 has potent toxicity and larvicidal effectiveness against Culex pipiens larvae with a LC₅₀ of 4 ng/mL. AChE/nAChR-IN-1 can be used as larvicides for mosquito-borne diseases research.

DL-4662 is a 3,4-dimethoxy derivative that can be identified using techniques such as, GC-EI-MS, LC-tandem mass spectrometry and NMR spectroscopy.

m-Chlorohippuric acid (3-Chlorohippuric acid) is a substituted hippurate and substrate for peptidylglycine α-hydroxylating monooxygenase (PHM). m-Chlorohippuric acid can be used in research on cancer, rheumatoid arthritis, depression, and pesticides.

5-Nitro-2-(bromoacetamido)benzophenone is a precursor or intermediate in the synthesis of benzodiazepines.

4-Aminobenzohydrazide (Standard) is the analytical standard of 4-Aminobenzohydrazide. This product is intended for research and analytical applications. 4-Aminobenzohydrazide (p-Aminobenzohydrazide) is an irreversible myeloperoxidase (MPO) inhibitor (IC50=0.3 μM) that induces oxidative stress burst in neutrophils (ROS IC50=43.6 μM). 4-Aminobenzohydrazide has been used in subacute stroke research.