SUN 1334H

Cat. No.: HY-U00084 Purity: 98.29%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K_i of 9.7 nM.

For research use only. We do not sell to patients.

SUN 1334H Chemical Structure

CAS No. : 607736-84-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of SUN 1334H:

SUN-1334H free base Get quote

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View All Histamine Receptor Isoform Specific Products:

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K_i of 9.7 nM.

IC₅₀ & Target

H₁ Receptor

In Vitro

SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC₅₀ (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K⁺-currents at concentrations as high as 100 μM^[1]. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs^[1]. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

489.38

Formula

C₂₃H₂₈Cl₂F₂N₂O₃

CAS No.

607736-84-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (204.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0434 mL	10.2170 mL	20.4340 mL
5 mM	0.4087 mL	2.0434 mL	4.0868 mL
10 mM	0.2043 mL	1.0217 mL	2.0434 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.29%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) HNMR (274 KB) RP-HPLC (304 KB) MS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. [Content Brief]

[2]. Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0434 mL	10.2170 mL	20.4340 mL	51.0850 mL
	5 mM	0.4087 mL	2.0434 mL	4.0868 mL	10.2170 mL
	10 mM	0.2043 mL	1.0217 mL	2.0434 mL	5.1085 mL
	15 mM	0.1362 mL	0.6811 mL	1.3623 mL	3.4057 mL
	20 mM	0.1022 mL	0.5109 mL	1.0217 mL	2.5543 mL
	25 mM	0.0817 mL	0.4087 mL	0.8174 mL	2.0434 mL
	30 mM	0.0681 mL	0.3406 mL	0.6811 mL	1.7028 mL
	40 mM	0.0511 mL	0.2554 mL	0.5109 mL	1.2771 mL
	50 mM	0.0409 mL	0.2043 mL	0.4087 mL	1.0217 mL
	60 mM	0.0341 mL	0.1703 mL	0.3406 mL	0.8514 mL
	80 mM	0.0255 mL	0.1277 mL	0.2554 mL	0.6386 mL
	100 mM	0.0204 mL	0.1022 mL	0.2043 mL	0.5109 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

SUN 1334H Related Classifications

Inflammation/Immunology Endocrinology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SUN 1334H607736-84-5Histamine ReceptorInhibitorinhibitorinhibit

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