Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
All Product Categories
-
Cathepsin Inhibitors
(218)
View all products
-
Cathepsin Antagonist
(1)
View all products
-
Cathepsin Activators
(7)
View all products
-
Cathepsin Inducers
(3)
View all products
-
Cathepsin Degrader
(1)
View all products
-
Cathepsin Control
(1)
View all products
-
Cathepsin Substrates
(21)
View all products
-
Cathepsin Ligand
(1)
View all products
-
Cathepsin Proteins
(35)
View all products
-
Cathepsin B Proteins
(5)
View all products
-
Cathepsin C Proteins
(4)
View all products
-
Cathepsin D Proteins
(5)
View all products
-
Cathepsin E Proteins
(3)
View all products
-
Cathepsin K Proteins
(1)
View all products
-
Cathepsin L1 Proteins
(4)
View all products
-
Cathepsin S Proteins
(2)
View all products
-
Cathepsin Related Products (301)
Related Products (301)
-
Recombinant Proteins (35)
-
Antibodies (6)
-
Cathepsin Isoform Comparison
-
BI-9740
0 ImagesCat. No.: HY-171888CAS No.: 1628596-25-7BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC50 of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation.
-
Cathepsin K inhibitor 5
0 ImagesCat. No.: HY-P10117CAS No.: 448945-62-8Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor.
-
Ctsc Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03326Ctsc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
GN-604
0 ImagesCat. No.: HY-183351GN-604 is a targeted drug conjugate (Targeted Drug Conjugate, TDC) formed by conjugation of GNS561 (HY-137978) with DN604, a Pt (II) complex. GN-604 selectively inhibits PPT1, induces lysosomal dysfunction, suppresses autophagy and triggers apoptosis. GN-604 promotes the targeted sequestration of Pt (II) inside cells, induces DNA damage and inhibits the proliferation of malignant cells. GN-604 is applicable to research related to triple-negative breast cancer.
-
Leupeptin hemisulfate (Standard)
0 ImagesLeupeptin hemisulfate (Standard) is the analytical standard of Leupeptin hemisulfate (HY-18234A ). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.
-
CPN4F
0 ImagesCat. No.: HY-189048CPN4F is a chalcone derivative with antiparasitic activity. CPN4F is an inhibitor of the cysteine protease cruzain. CPN4F forms a key hydrogen bond with the Trp-184 residue in the active site of parasitic cruzain as an electrophile, and induces oxidative stress, cell membrane degradation, and necrosis, thereby inhibiting parasite proliferation. CPN4F is used in research related to Chagas disease.
-
Ctsb Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03324Ctsb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
TB-9
0 ImagesCat. No.: HY-164956CAS No.: 1415033-91-8TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC50s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.
-
Cathepsin K-IN-8
0 ImagesCat. No.: HY-177315CAS No.: 501126-27-8Cathepsin K-IN-8 (cxample 6-60) is a cathepsin K inhibitor that can be used for the study of inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.
-
Anti-inflammatory agent 113
0 ImagesCat. No.: HY-181676Anti-inflammatory agent 113 (compound B5) is a Cathepsin L (CTSL) inhibitor and anti-inflammatory agent with a CTSL IC50 of 5.52 μM. Anti-inflammatory agent 113 suppresses CTSL maturation, attenuates NF-κB and p38 MAPK signaling pathway activation, and binds stably in CTSL’s active site via noncovalent interactions with Asp162, Cys25, and Glu63. Anti-inflammatory agent 113 inhibits pro-inflammatory cytokine (IL-6, IL-8) production, reduces inflammatory cell lung infiltration, and alleviates lung tissue injury. Anti-inflammatory agent 113 can be used for the research of acute lung injury.
-
BJ-2302
0 ImagesCat. No.: HY-182614CAS No.: 1631056-29-5BJ-2302 is a Src kinase inhibitor with an IC50 of 3.23 μM, and inhibits cathepsin S (CTSS) activity.BJ-2302 binds to Src, suppresses PI3K/AKT and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression.BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth.BJ-2302 does not induce cytotoxicity in normal breast epithelial cells.BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer.
-
CTSK Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03337CTSK Human Pre-designed siRNA Set A contains three designed siRNAs for CTSK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Verducatib
0 ImagesVerducatib (BI 1291583) is an orally active inhibitor of cathepsin C (also known as DPP1). Verducatib restores the protease-inhibitor balance by inhibiting the activation of neutrophil serine proteases, thereby alleviating pulmonary inflammation and regulating infection responses. Verducatib significantly reduces the risk (including severe exacerbations) and frequency of acute exacerbations in bronchiectasis (BE). Verducatib also improves lung function and quality of life, and shortens the duration of antibiotic use. The overall incidence of adverse events of Verducatib is comparable to that of placebo, with only slightly more mild-to-moderate cutaneous adverse events observed in the high-dose group, demonstrating promising clinical application potential.
-
BI-1124
0 ImagesCat. No.: HY-171925CAS No.: 752237-69-7BI-1124 is a cathepsin S inhibitor that exhibits simulated sufficient ocular pharmacokinetic-pharmacodynamic coverage in rabbit models via topical ocular administration. BI-1124 can be used for the research of age-related dry eye disease.
-
FGA145
0 ImagesCat. No.: HY-161244FGA145 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 3.71 μM, 9.82 μM and 53 nM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity.
-
Cathepsin C-IN-6
0 ImagesCat. No.: HY-155611Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase，exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g.，chronic obstructive pulmonary disease).
-
Alkyne-GRWHPM-CONH-NH-CMK
0 ImagesCat. No.: HY-P11857Alkyne-GRWHPM-CONH-NH-CMK is a covalent Cathepsin S inhibitor (IC50=82 nM). Alkyne-GRWHPM-CONH-NH-CMK has an N-terminal alkyne handle for CuAAC functionalization that engages off-target protein disulfide isomerase PDIA1. Alkyne-GRWHPM-CONH-NH-CMK can be used for the research of autoimmune disorders.
-
AM4299B
0 ImagesCat. No.: HY-120288CAS No.: 160825-49-0AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and papain with IC50s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent.
