Cathepsin
Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.
Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.
Cathepsin Isoform Specific Products
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Cathepsin Inhibitors
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Cathepsin Antagonist
(1)
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Cathepsin Activators
(7)
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Cathepsin Inducers
(3)
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Cathepsin Degrader
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Cathepsin Control
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Cathepsin Substrates
(21)
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Cathepsin Ligand
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Cathepsin Proteins
(35)
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Cathepsin B Proteins
(5)
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Cathepsin C Proteins
(4)
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Cathepsin D Proteins
(5)
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Cathepsin E Proteins
(3)
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Cathepsin K Proteins
(1)
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Cathepsin L1 Proteins
(4)
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Cathepsin S Proteins
(2)
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Cathepsin Related Products (301)
Related Products (301)
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Recombinant Proteins (35)
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Antibodies (6)
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Cathepsin Isoform Comparison
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Cathepsin K inhibitor 4
0 ImagesCat. No.: HY-P10061Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC50s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively.
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Ctsk Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03338Ctsk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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NB-533
0 ImagesCat. No.: HY-182429CAS No.: 1146544-18-4NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC50 of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC50 of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ40 release. NB-533 reduces brain levels of APP metabolite C99 and Aβ40 in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease.
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Ctse Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03332Ctse Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctse gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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BI-1915
0 ImagesCat. No.: HY-172203CAS No.: 752237-67-5BI-1915, a chemical probe, is the selective inhibitor for Cathepsin S with an IC50 of 17 nM. BI-1915 can be used in research of autoimmune diseases.
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Cathepsin C-IN-3
0 ImagesCat. No.: HY-146580CAS No.: 2825567-71-1Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively.
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N-Ethylmaleimide (Standard)
0 ImagesBayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition.
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Ctsl Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03341Ctsl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cathepsin L-IN-7
0 ImagesCat. No.: HY-183940CAS No.: 1194047-02-3Cathepsin L-IN-7 is an inhibitor of cathepsin L, cathepsin B and cathepsin S. Cathepsin L-IN-7 has an IC50 of 0.011 μM against cathepsin L and an IC50 of 0.062 μM against cathepsin S, while it shows weak inhibitory activity against cathepsin B. Cathepsin L-IN-7 binds to the active site of cysteine proteases and blocks their proteolytic function. Cathepsin L-IN-7 can be used in research on viral infections and cancer.
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NB-216
0 ImagesCat. No.: HY-11014CAS No.: 943924-04-7NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM). NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM). NB-216 can be used for the study of Alzheimer's disease.
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Cathepsin C-IN-7
0 ImagesCat. No.: HY-177408CAS No.: 77180-19-9Cathepsin C-IN-7 (Page 68) is a Cathepsin C inhibitor. Cathepsin C-IN-7 can be used in research related to primary cancers and cancer metastases.
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MV061194
0 ImagesCat. No.: HY-15101CAS No.: 1021423-50-6MV061194 is a selective cathepsin K inhibitor with a human Ki of 2.5 nM. MV061194 can be used for the research of osteoporosis.
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MK-0674
0 ImagesCat. No.: HY-10290CAS No.: 887781-62-6MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
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LmCPB-IN-1
0 ImagesCat. No.: HY-146649CAS No.: 2151025-98-6LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pKi of 9.7.
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ASPER-29
0 ImagesCat. No.: HY-152210CAS No.: 2630388-03-1ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer.
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CAA-0225
0 ImagesCat. No.: HY-16121CAS No.: 244072-26-2CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
