Cholinesterase (ChE)
Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.
There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.
Cholinesterase (ChE) Isoform Specific Products
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Cholinesterase (ChE) Inhibitors
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Cholinesterase (ChE) Related Products (1096)
Related Products (1096)
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Antibodies (2)
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Cholinesterase (ChE) Isoform Comparison
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Aposcopolamine (Standard)
0 ImagesAposcopolamine (Standard) is the analytical standard of Aposcopolamine. This product is intended for research and analytical applications. Aposcopolamine is an alkaloid that can be isolated from Datura ferox. Aposcopolamin can closely binds with ACHE, ADRA2A and CHRM2. Aposcopolamine can be used for the research of Alzheimer's disease.
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1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
0 ImagesCat. No.: HY-W276446CAS No.: 968-63-81,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Tropatepine (Standard)
0 ImagesTropatepine (Standard) is the analytical standard of Tropatepine (HY-105710). This product is intended for research and analytical applications. Tropatepine is an orally active anticholinergic agent and can be used in the research of neurological diseases such as Parkinson's disease and extrapyramidal syndromes.
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AChE/nAChR-IN-1
0 ImagesCat. No.: HY-175607CAS No.: 59417-09-3
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Garcinol (Standard)
0 ImagesCat. No.: HY-107569RCAS No.: 78824-30-3Garcinol (Standard) is the analytical standard of Garcinol. This product is intended for research and analytical applications. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.
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Arisugacin H
0 ImagesCat. No.: HY-N13928CAS No.: 261951-59-1Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE.
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Physostigmine salicylate (Standard)
0 ImagesPhysostigmine (salicylate) (Standard) is the analytical standard of Physostigmine (salicylate). This product is intended for research and analytical applications. Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.
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Piperilate hydrochloride
0 ImagesCat. No.: HY-105790ACAS No.: 4544-15-4Piperilate (Pipethanate) hydrochloride is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate hydrochloride also causes hypotension and rescues mice poisoned by the organophosphates.
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Fenchlorphos (Standard)
0 ImagesFenchlorphos (Standard) is the analytical standard of Fenchlorphos. This product is intended for research and analytical applications. Fenchlorphos, an organophosphate, is an insecticide. Fenchlorphos is an inhibitor of the enzyme acetylcholinesterase (AChE). Fenchlorphos is able to cause mitochondrial dysfunction.
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Heterophos
0 ImagesCat. No.: HY-W783157CAS No.: 40626-35-5Synonyms: HeterofosHeterophos (Heterofos) is an organophosphorus insecticide and an AChE inhibitor. Heterophos inhibits AChE's function of decomposing acetylcholine, causing disorder of insect nerve conduction and exerting insecticidal effects.
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Dihydrokaempferol-3-O-β-D-glucoside
0 ImagesCat. No.: HY-N12833CAS No.: 31049-08-8Dihydrokaempferol-3-O-β-D-glucoside (Compound 3) is a compound that can be isolated from the bark of Cudrania tricuspidata (Carr.) Bur. . Dihydrokaempferol-3-O-β-D-glucoside is an inhibitor of acetylcholinesterase (AChE).
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Anabasamine
0 ImagesCat. No.: HY-116041CAS No.: 20410-87-1
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Rivastigmine-d4 tartrate
0 ImagesCat. No.: HY-W654335Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
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Ubretid (Standard)
0 ImagesCat. No.: HY-119577RCAS No.: 15876-67-2Synonyms: Distigmine dibromide (Standard)Ubretid (Standard) is the analytical standard of Ubretid. This product is intended for research and analytical applications. Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder.
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Tacrine hydrochloride hydrate (Standard)
0 ImagesTacrine (hydrochloride) (hydrate) (Standard) is the analytical standard of Tacrine (hydrochloride) (hydrate). This product is intended for research and analytical applications. Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
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Itameline
0 ImagesCat. No.: HY-U00085CAS No.: 145071-44-9Synonyms: RU 47213Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat.
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Galactamine
0 ImagesGalactamine is an AChE inhibitor. Galactamine can be used in the research of Alzheimer's disease.
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Itopride-d6
0 ImagesCat. No.: HY-B0732ASCAS No.: 1346746-82-4Synonyms: HSR803-d6 free baseItopride-d6 (HSR803-d6 (free base)) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
