2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116975
    Enoxastrobin
    		Inhibitor
    Enoxastrobin (Enestroburin) is an anti-fungal agent. Enoxastrobin is active against P. oryzae and B. cinerea.
    Enoxastrobin
  • HY-W017611S
    4-Propylphenol-d12
    		Inhibitor
    4-Propylphenol-d12 is the deuterium labeled 4-Propylphenol. 4-Propylphenol is a plant-derived phenolic compound. 4-Propylphenol causes an increase in ROS within the Fusarium graminearum cells, leading to damage to the DNA and cell membranes of the mycelia, effectively inhibiting the growth of the mycelia. 4-Propylphenol also has a growth inhibitory effect on walnut pathogenic fungi (C. gloeosporioides, C. siamense, A. alternata), with its EC50 ranging from 29.11 to 31.89 mg/L, and it also inhibits spore germination, with EC50 being 55.04-71.85 mg/L. 4-Propylphenol can be used in the research of fungal diseases in walnuts and wheat Fusarium head blight.
    4-Propylphenol-d<sub>12</sub>
  • HY-168066
    Antifungal agent 117
    		Inhibitor
    Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection.
    Antifungal agent 117
  • HY-177042
    Hsp90-IN-41
    		Inhibitor
    Hsp90-IN-41 (Compound C1) is an inhibitor of Hsp90 (IC50 = 0.044 μM). Hsp90-IN-41 exhibits antifungal and antitumor (IC50 = 0.049 μM) activities in vitro.
    Hsp90-IN-41
  • HY-144694
    HDAC/HSP90-IN-3
    		Inhibitor
    HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.
    HDAC/HSP90-IN-3
  • HY-119502R
    Camalexin (Standard)
    		Inhibitor
    Camalexin (Standard) is the analytical standard of Camalexin. This product is intended for research and analytical applications. Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].
    Camalexin (Standard)
  • HY-172363
    Succinate dehydrogenase-IN-6
    		Inhibitor
    Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC50 of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC50s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC50 > 12.5 μg/mL).
    Succinate dehydrogenase-IN-6
  • HY-19377
    SS-750
    		Inhibitor
    SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC90 values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans.
    SS-750
  • HY-W665208
    Zapotin
    		Inhibitor
    Zapotin is a member of the polymethoxyflavones, which are natural polyphenols from the group of flavonoid. Zapotin exhibits antidepressant, anticancer, antifungal, and antioxidant activity. Zapotin is a chemopreventive and chemotherapeutic agent. Zapotin can result in a reduction of large aberrant crypt foci in CF-1 mouse model. Zapotin inhibits autophagosome formation. Zapotin has inhibitory activity in mouse mammary organ culture with an IC50 of 50 µg/mL.
    Zapotin
  • HY-162776
    Succinate dehydrogenase-IN-3
    		Inhibitor
    Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity.
    Succinate dehydrogenase-IN-3
  • HY-N11505
    Isopicropodophyllone
    		Inhibitor
    Isopicropodophyllone, a natural compound that can be isolated from leaves of Podophyllum hexandrum, possesses antifungal activity.
    Isopicropodophyllone
  • HY-B1978S
    Iprodione-d5
    Iprodione-d5 is the deuterium labeled Iprodione. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective.
    Iprodione-d<sub>5</sub>
  • HY-168648
    DNA Gyrase/DHFR-IN-1
    		Inhibitor
    DNA Gyrase/DHFR-IN-1 is a dual inhibitor of bacterial DNA gyrase and DHFR, with IC50s of 182 μM and 3.90 μM for E. coli DNA gyrase and DHFR respectively. DNA Gyrase/DHFR-IN-1 has bactericidal and antifungal activity.
    DNA Gyrase/DHFR-IN-1
  • HY-N3457
    Isosativan
    		Inhibitor
    Isosativan is a natural product that can be found in Trifolium hybridum. Isosativan shows antifungal activity.
    Isosativan
  • HY-N19314
    4-Acetylantroquinonol B
    4-Acetylantroquinonol B is a benzoquinone derivative and a hepatocellular carcinoma cell proliferation inhibitor. 4-Acetylantroquinonol B can be isolated from the mycelia of Antrodia cinnamomea cultured via submerged fermentation. 4-Acetylantroquinonol B exhibits selective activity against hepatocellular carcinoma cells and can be used in hepatocellular carcinoma research.
    4-Acetylantroquinonol B
  • HY-136915
    Pyrisoxazole
    		Inhibitor
    Pyrisoxazole (SYP-Z048) is a fungicide.
    Pyrisoxazole
  • HY-W753181
    (S)-2-Hydroxy-3-phenylpropanoic acid-13C9
    (S)-2-Hydroxy-3-phenylpropanoic acid-13C9 (L-(-)-3-Phenyllactic Acid-13C9) is the 13C-labeled (S)-2-Hydroxy-3-phenylpropanoic acid (HY-30220). (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria.
    (S)-2-Hydroxy-3-phenylpropanoic acid-<sup>13</sup>C<sub>9</sub>
  • HY-N10267
    Carviolin
    Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.
    Carviolin
  • HY-N10482
    Tinophyllol
    		Inhibitor 98.05%
    Tinophyllol, a furanoditerpenoid, is a natural product found in Arcangelisia flava MERR. Tinophyllol has good activity against Botrytis cinerea.
    Tinophyllol
  • HY-153622
    Antifungal agent 57
    		Inhibitor
    Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candida albicans strains with MIC values of 0.5-2 μg/mL.
    Antifungal agent 57
Cat. No. Product Name / Synonyms Application Reactivity