2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N8120
    Bisabolone oxide A
    		Inhibitor
    Bisabolone oxide A is an α-glucosidase inhibitor.
    Bisabolone oxide A
  • HY-154972
    α-Amylase/α-Glucosidase-IN-3
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-3 (Compound 17) is an α-Amylase/α-Glucosidase dual inhibitor, with IC50s of 0.70 μM and 1.10 μM. α-Amylase/α-Glucosidase-IN-3 can be used for research of type-II diabetes mellitus.
    α-Amylase/α-Glucosidase-IN-3
  • HY-125426
    ToP-DNJ
    		Inhibitor
    ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC50 value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection.
    ToP-DNJ
  • HY-180937
    CHI3L1-IN-6
    		Inhibitor
    CHI3L1-IN-6 (Compound 9e) is a CHI3L1 inhibitor with a Kd of 19.11 μM for hCHI3L1. CHI3L1-IN-6 blocks CHI3L1-Galectin-3 interaction. CHI3L1-IN-6 reduces STAT3 signaling. CHI3L1-IN-6 exhibits anti-cancer activity against glioblastoma.
    CHI3L1-IN-6
  • HY-N19646
    [8]-Dehydrogingerdione
    		Inhibitor
    [8]-Dehydrogingerdione is a Hydroxyphenylalkanone. [8]-Dehydrogingerdione can be isolated from the seeds of Aframomum melegueta and the rhizomes of Curcuma xanthorrhia. [8]-Dehydrogingerdione acts as an inhibitor of α-glucosidase and Tyrosinase, with an IC50 value of 19.5 μM against α-glucosidase and an approximate IC50 value of 100 μM against tyrosinase. [8]-Dehydrogingerdione can be used in diabetes-related research.
    [8]-Dehydrogingerdione
  • HY-161318
    α-Glucosidase-IN-52
    		Inhibitor
    α-Glucosidase-IN-52 (Compound 3h) is an α-glucosidase inhibitor with an IC50 of 2.8 μM. α-Glucosidase-IN-52 can be used for diabetes research.
    α-Glucosidase-IN-52
  • HY-174840
    α-Glucosidase-IN-94
    		Inhibitor
    α-Glucosidase-IN-94 (Compound 6e) is a potent α-glucosidase inhibitor with an IC50 value of 0.1412 mM. α-Glucosidase-IN-94 is promising for research of type 2 diabetes.
    α-Glucosidase-IN-94
  • HY-E70880A
    Endoglycosidase CC
    Endoglycosidase CC (EndoCC), an endoglycosidase, is a substrate of glycopeptide.
    Endoglycosidase CC
  • HY-151141
    α-Glucosidase-IN-17
    		Inhibitor
    α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity.
    α-Glucosidase-IN-17
  • HY-161429
    Antidiabetic agent 5
    		Inhibitor
    Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes.
    Antidiabetic agent 5
  • HY-151145
    α-Glucosidase-IN-21
    		Inhibitor
    α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity.
    α-Glucosidase-IN-21
  • HY-181353
    α-Glucosidase-IN-112
    		Inhibitor
    α-Glucosidase-IN-112 is an α-glucosidase inhibitor with an IC50 of 2.03 μM and a Ki of 0.44 μM. α-Glucosidase-IN-112 exerts antioxidant effects by scavenging ABTS+ free radicals. α-Glucosidase-IN-112 exerts antiproliferative effects by inhibiting the proliferation of bladder cancer cells. α-Glucosidase-IN-112 can be used in research related to type 2 diabetes and bladder cancer.
    α-Glucosidase-IN-112
  • HY-P992234
    Anti-Heparanase Antibody
    Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-Heparanase Antibody
  • HY-169292
    Antitumor agent-188
    		Inhibitor
    Antitumor agent-188 (compound C6) exerts α-glucosidase inhibitory activity, and antitumor effects.Antitumor agent-188 induces excessive production of ROS to trigger oxidative stress.
    Antitumor agent-188
  • HY-182460
    Gambogin
    		Inhibitor
    Gambogin is an α-glucosidase inhibitor, found in the resin and dry latex of Garcinia hanburyi. Gambogin exists as an inseparable diastereomeric pair of C-2 epimers (8a and 8b), with 8a having an α-glucosidase inhibitory IC50 of 209.2 μM and 8b showing α-glucosidase inhibitory IC50 > 300 μM. Gambogin can be used for the research of type 2 diabetes and cervical cancer.
    Gambogin
  • HY-138992
    2,3-Indolobetulin
    		Inhibitor
    2,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin. 2,3-Indolobetulin can be used in the synthesis of α-glucosidase inhibitors.
    2,3-Indolobetulin
  • HY-151144
    α-Glucosidase-IN-20
    		Inhibitor
    α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity.
    α-Glucosidase-IN-20
  • HY-N3962R
    Glycyrrhisoflavone (Standard)
    		Inhibitor
    Glycyrrhisoflavone (Standard) is the analytical standard of Glycyrrhisoflavone. This product is intended for research and analytical applications. Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase.
    Glycyrrhisoflavone (Standard)
  • HY-E70890
    β-Galactosidase Mutein, E. coli
    β-Galactosidase Mutein, E. coli is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.
    β-Galactosidase Mutein, E. coli
  • HY-E71307
    β-L-Rhamnosidase
    β-L-Rhamnosidase (EC 3.2.1.43) belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O-and S-glycosyl compounds.
    β-L-Rhamnosidase
Cat. No. Product Name / Synonyms Application Reactivity