CBP/p300 Inhibitor

CBP/p300 Inhibitors (21):

Cat. No.	Product Name	Effect	Purity

HY-N0005

Curcumin	Inhibitor	≥98.0%
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.

HY-N2020

Anacardic Acid	Inhibitor	98.07%
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ∼8.5 μM and ∼5 μM, respectively.

HY-101084

NSC 228155	Inhibitor	≥98.0%
NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR.

HY-124696

PU139	Inhibitor	98.03%
PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor.

HY-100482

CPI-637	Inhibitor	99.94%
CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC₅₀ values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC₅₀ of 0.3 μM for CBP.

HY-128875

CBP/p300-IN-10	Inhibitor	98.69%
CBP/p300-IN-10 is a highly potent histone acetyltransferase EP300 and CREBBP with IC₅₀ values of 26 nM and 39 nM, respectively.

HY-151812

CBP/p300-IN-20	Inhibitor
CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC₅₀ of 10.1 for p300.

HY-19999A

PF-CBP1 hydrochloride	Inhibitor	99.99%
PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD).

HY-104068

Naphthol AS-E	Inhibitor	≥98.0%
Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction.

HY-110263

EML 425	Inhibitor	98.16%
EML425 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC₅₀s of 2.9 and 1.1 μM, respectively.

HY-120028

GNE-207	Inhibitor
GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC₅₀ of 1 nM, exhibits a selectively index of >2500-fold against BRD4 (1).

HY-139149

NiCur	Inhibitor	99.09%
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 0.35 μΜ.

HY-131035

Lys-CoA TFA	Inhibitor	99.42%
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC₅₀=50-500 nM).

HY-112610

CF53	Inhibitor	99.78%
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a K_i of <1 nM, K_d of 2.2 nM and an IC₅₀ of 2 nM for BRD4 BD1.

HY-143443

DS17701585	Inhibitor
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC₅₀ values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and SOX2.

HY-143442

CBP/p300-IN-18	Inhibitor
CBP/p300-IN-18 (compound 8) is a potent EP300/CBP HAT inhibitor with IC₅₀s of 0.056, 0.46 µM for HAT EP300 and LK2 H3K27, respectively.

HY-143339

CBP/p300-IN-15	Inhibitor
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC₅₀ values of 2.50 and 28.0 nM, respectively.

HY-147261

B026	Inhibitor
B026 is a selective, potent, orally active p300/CBP histone acetyltransferase (HAT) inhibitor with IC₅₀ values of 1.8 nM and 9.5 nM for p300 and CBP enzyme, respectively.

HY-143441

CBP/p300-IN-17	Inhibitor
CBP/p300-IN-17 (compound 7) is a potent EP300/CBP HAT inhibitor with IC₅₀s of 0.18, 0.69 µM for HAT EP300 and LK2 H3K27, respectively.

HY-146277

CBP/p300-IN-19	Inhibitor
CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively.

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