PPAR
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating gene expression. There are three main isoforms: PPARα, PPARβ/δ, and PPARγ, each with distinct tissue distribution and biological roles. PPARα is primarily expressed in liver, heart, and muscle, where it regulates fatty acid oxidation and lipid metabolism[1]. PPARβ/δ is widely expressed and involved in energy homeostasis, glucose metabolism, and inflammation modulation[1]. PPARγ is highly expressed in adipose tissue and plays a central role in adipogenesis, insulin sensitivity, and lipid storage[2].
References:
- [1]. Man versus microbe. Nat Med. 2004 Dec;10(12 Suppl):S69. doi: 10.1038/nm1149. PMID: 15577933; PMCID: PMC7096048. et al. Nat Med. 2004 Dec;10(12 Suppl):S69. [Content Brief]
- [2]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]
- [3]. Brent J, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med. 1999 Mar 18;340(11):832-8. [Content Brief]
- [4]. Liu Y, et al. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat Med. 2006 May;12(5):518-25. [Content Brief]
- [5]. Paranjape AN, et al. Introduction of SV40ER and hTERT into mammospheres generates breast cancer cells with stem cell properties. Oncogene. 2012 Apr 12;31(15):1896-909. [Content Brief]
- [6]. Iancu-Rubin C, et al. Whirling Platelets Away for Transfusion. Cell. 2018 Jul 26;174(3):503-504. [Content Brief]
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PPAR Related Products (396)
Related Products (396)
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4-Oxo Docosahexaenoic Acid
0 ImagesCat. No.: HY-134997CAS No.: 845673-74-7Synonyms: 4-oxo DHA4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.
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CUDA-d11
0 ImagesCat. No.: HY-121538SCUDA-d11 is deuterium labeled CUDA (HY-121538). CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease.
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Keracyanin chloride (Standard)
0 ImagesCat. No.: HY-105935RCAS No.: 18719-76-1Synonyms: Cyanidin 3-rutinoside chloride (Standard); Cyanidin 3-O-rutinoside chloride (Standard); Sambucin chloride (Standard)Keracyanin (chloride) (Standard) is the analytical standard of Keracyanin (chloride). This product is intended for research and analytical applications. Keracyanin chloride inhibits NF-κB/FAK/MAPK signaling pathway. Keracyanin chloride exhibits antioxidant, anti-inflammatory and hypoglycemic effects, and is orally active.
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CAY10514
0 ImagesCat. No.: HY-118514CAS No.: 868526-38-9CAY10514 is an aromatic of 8(S)-HETE. CAY10514 acts as a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ with IC50 of 0.173 and 0.642 μM, respectively.
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GW0742 (Standard)
0 ImagesSynonyms: GW610742 (Standard)GW0742 (Standard) is the analytical standard of GW0742. This product is intended for research and analytical applications. GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
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ZINC08438472
0 ImagesCat. No.: HY-114700CAS No.: 443872-20-6ZINC08438472 is a potent and selective peroxisome proliferator activated receptors-α (PPAR-α) agonist with an EC50 value of 12.1 nM. ZINC08438472 is promising for research of diabetes, hyperlipidaemia and inflammatory disorders.
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Cinnamyl Alcohol (Standard)
0 ImagesCinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohole (HY-Y0078). This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.
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Retinoic acid-d3-1
0 ImagesCat. No.: HY-14649S6CAS No.: 3041101-53-2Synonyms: Vitamin A acid-d3-1; all-trans-Retinoic acid-d3-1; ATRA-d3-1Retinoic acid-d3-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
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Maltitol (Standard)
0 ImagesMaltitol (Standard) is the analytical standard of Maltitol (HY-B2122). This product is intended for research and analytical applications. Maltitol is an orally active polyol and sugar alcohol sweetener produced by the hydrogenation of maltose. Maltitol can replace sucrose and has characteristics of having a minor impact on blood sugar and potential prebiotic effects.
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GW9662 (Standard)
0 ImagesGW9662 (Standard) is the analytical standard of GW9662. This product is intended for research and analytical applications. GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
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TBBPA-sulfate
0 ImagesCat. No.: HY-148083CAS No.: 902525-22-8TBBPA-sulfate is metabolite of TBBPA. TBBPA has been reported to enhance adipogenesis by binding with the peroxisome proliferator-activated receptor gamma (PPARγ).
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Neomangiferin (Standard)
0 ImagesNeomangiferin (Standard) is the analytical standard of Neomangiferin. This product is intended for research and analytical applications. Neomangiferin is an orally active natural flavonoid. Neomangiferin partially ameliorates non-alcoholic fatty liver disease (NAFLD) by regulating the expression of genes related to free fatty acid uptake and lipid oxidation. Neomangiferin exerts anti-colitis effects by inhibiting Th17/Treg cell differentiation. Neomangiferin exerts anti-aging and lifespan-extending effects by targeting upregulation of bas-1, which in turn activates the autophagy, IIS and MAPK pathways. Neomangiferin has the potential to prevent aseptic loosening of prostheses after total joint arthroplasty due to its significant anti-inflammatory and osteoclastogenesis-inhibiting effects.
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PPARα/γ/δ agonist 1
0 ImagesCat. No.: HY-119197CAS No.: 853652-40-1PPARα/γ/δ agonist 1 (Compound 2) is a potent PPARα/γ/δ agonist, with an IC50 of 70 nM for PPARγ. PPARα/γ/δ agonist 1 can be used for the research of type 2 diabetes.
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Chiglitazar (Standard)
0 ImagesCat. No.: HY-106266RCAS No.: 743438-45-1Synonyms: Carfloglitazar (Standard)Chiglitazar (Standard) is the analytical standard of Chiglitazar (HY-106266). This product is intended for research and analytical applications. Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.
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BM152054
0 ImagesCat. No.: HY-U00259CAS No.: 213411-84-8BM152054 is a potent PPARgamma-activator. BM152054 can promote glucose utilization in peripheral tissues by enhancing insulin action.
