Sirtuin
Sirtuins are a conserved family of NAD+-dependent deacylases and class III histone deacetylases that couple cellular energy status to transcriptional and metabolic regulation, thereby influencing stress adaptation, genome maintenance, and cellular homeostasis[1][2]. Mechanistically, sirtuins respond to fluctuations in NAD+ availability and regulate pathways associated with oxidative stress resistance, mitochondrial function, DNA repair, and metabolic efficiency through deacylation of histone and non-histone protein targets[2][3][4]. These activities place sirtuins at the intersection of nutrient sensing and cellular responses to environmental and physiological perturbations, including fasting, caloric restriction, DNA damage, and redox imbalance[2][4]. In disease-relevant contexts and experimental models, altered sirtuin activity has been linked to aging-related functional decline, metabolic disorders, inflammation, and impaired mitochondrial homeostasis, making the family an important framework for mechanistic studies of age-associated pathophysiology[2][5]. Compared with related isoforms, mammalian SIRT1-SIRT7 display distinct subcellular localization and biological functions, with SIRT1, SIRT6, and SIRT7 enriched mainly in the nucleus, SIRT2 primarily localized in the cytoplasm, and SIRT3, SIRT4, and SIRT5 concentrated in mitochondria, supporting isoform-specific regulation of cellular processes[1][3]. For experimental applications, sirtuin-modulating compounds, including sirtuin-activating compounds and inhibitors such as nicotinamide, are widely used to investigate NAD+-dependent signaling networks and the contribution of individual sirtuin isoforms to metabolism, aging, and disease mechanisms[5][6].
References:
- [1]. Zhao L, et al. Sirtuins and their Biological Relevance in Aging and Age-Related Diseases. Aging Dis. 2020 Jul 23;11(4):927-945. [Content Brief]
- [2]. Imai S, et al. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. [Content Brief]
- [3]. Shahgaldi S, et al. A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism. Life Sci. 2021;282:119803.
- [4]. Imai S, et al. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis. 2016;2:16017.
- [5]. Bonkowski MS, et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. [Content Brief]
- [6]. Wikipedia.
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Sirtuin Related Products (151)
Related Products (151)
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Antiproliferative agent-17
0 ImagesCat. No.: HY-152090CAS No.: 2882206-08-6Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity.
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SIRT2-IN-10
0 ImagesCat. No.: HY-151522CAS No.: 296793-09-4SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease.
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SIRT1 activator 1
0 ImagesCat. No.: HY-N12386SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway.
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Tenovin-D3 hydrochloride
0 ImagesCat. No.: HY-123994CAS No.: 1258283-70-3Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner.
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Schisanhenol (Standard)
0 ImagesCat. No.: HY-N0859RCAS No.: 69363-14-0Synonyms: Schizanhenol (Standard); Gomisin-K3 (Standard)Schisanhenol (Standard) (Schizanhenol (Standard)) is the analytical standard of Schisanhenol (HY-N0859). This product is intended for research and analytical applications. Schisanhenol, a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration.
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SIRT5 inhibitor 8
0 ImagesCat. No.: HY-149524CAS No.: 3054055-22-7SIRT5 inhibitor 8 (compound 10) is a competitive inhibitor (IC50: 5.38 μM) of sirtuin SIRT5 with anticancer potential.
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SIRT5 inhibitor 6
0 ImagesCat. No.: HY-149425CAS No.: 2834736-82-0SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo.
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CypD-IN-5
0 ImagesCat. No.: HY-116095CAS No.: 1572646-93-5CypD-IN-5 (compound C-9) is a potent cyclophilin D (CypD) inhibitor. CypD-IN-5 can be used in the study of Alzheimer's disease.
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Guttiferone G
0 ImagesCat. No.: HY-N9892CAS No.: 666174-75-0Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla.
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Nicotinamide (GMP)
0 ImagesNicotinamide (GMP) (Niacinamide (GMP)) is the GMP level of Nicotinamide (HY-B0150). GMP guidelines are used to produce Nicotinamide (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
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SIRT2-IN-12
0 ImagesCat. No.: HY-162252CAS No.: 3049202-51-6SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with a IC50 value of 50 μM.
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SIRT5 inhibitor 9
0 ImagesCat. No.: HY-149525CAS No.: 3054055-26-1SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor (IC50: 4.07 μM) of sirtuin SIRT5 with anticancer potential.
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β-Curcumene
0 Imagesβ-Curcumene is a sesquiterpene compound. β-Curcumene has the potential to act as a SIRT1 activator and a NF-κB inhibitor. β-Curcumene possesses a spicy and ginger-like aroma, and can serve as a raw material for flavors, fragrances and cosmetics. β-Curcumene can be used in the research of type 2 diabetes.
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AGK7
0 ImagesCat. No.: HY-119857CAS No.: 304896-21-7Synonyms: SIRT2 Inhibitor,Inactive ControlAGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease.
