Antiproliferative agent-17
Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2882206-08-6
- Formula: C26H28N2OS
- Molecular Weight:416.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antiproliferative agent-17 (compound 5e) shows activity against the Gram-positive bacteria Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007 and Micrococcus luteus IFO 3232. Antiproliferative agent-17 has no activity against the tested Gram-negative bacteria and fungi[1].
Antiproliferative agent-17 (compound 5e) displays anti-proliferative activity with IC50 values of 12.85 μM, 11.96 μM, 16.30 μM, 9.87 μM, and 6.90 μM for PC-3 (human prostate cancer), HCT-116 (human colorectal cancer), HepG-2 (human hepatocellular cancer), HeLa (human cervical cancer), and MCF-7 (human breast cancer), respectively[1].
Antiproliferative agent-17 (compound 5e) binds to the active site of the SIRT1 enzyme, occupying the positions of the NAD cofactor and the known histone deacetylase inhibitor EX527[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2882206-08-6
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Molecular Weight 416.58
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Formula C26H28N2OS
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SMILES
COC1=CC=C(C2=CS/C(N2C3=CC=CC=C3)=N\C45CC6CC(C5)CC(C6)C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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