Antiproliferative agent-17 

Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity^[1].

Antiproliferative agent-17 (compound 5e) shows activity against the Gram-positive bacteria Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007 and Micrococcus luteus IFO 3232. Antiproliferative agent-17 has no activity against the tested Gram-negative bacteria and fungi^[1].
Antiproliferative agent-17 (compound 5e) displays anti-proliferative activity with IC₅₀ values of 12.85 μM, 11.96 μM, 16.30 μM, 9.87  μM, and 6.90 μM for PC-3 (human prostate cancer), HCT-116 (human colorectal cancer), HepG-2 (human hepatocellular cancer), HeLa (human cervical cancer), and MCF-7 (human breast cancer), respectively^[1].
Antiproliferative agent-17 (compound 5e) binds to the active site of the SIRT1 enzyme, occupying the positions of the NAD cofactor and the known histone deacetylase inhibitor EX527^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.58

C₂₆H₂₈N₂OS

2882206-08-6

COC1=CC=C(C2=CS/C(N2C3=CC=CC=C3)=N\C45CC6CC(C5)CC(C6)C4)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Eman T Warda, et al. Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds. Sci Rep. 2022 Dec 6;12(1):21058.  [Content Brief]